Research Interest: Obesity and diabetes mainly involving the early stages of life (pregnancy and lactation), research is related to the concept DoHAD (Developmental Origins of Health and Disease, areas of metabolic diseases and physical exercise.

Research Interest: Preparation and tissue fabrication of novel biomedical materials;Novel bioreactor technology and its application, Control of expansion and differentiation of stem cells, Construction, numerical simulation and optimization of dynamic culture systems, Regulation of active component of traditional Chinese medicine on proliferation and differentiation of stem cells

Research Interest: Genetic disorder, splicing mutations, Cornelia de Lange Syndrome, HMG-CoA lyase deficiency, HMG-CoA synthase deficiency

Research Interest: Role of Sex Hormones in Various Pathophysiologies with specific relevance to Women’s Health,role of hormone metabolism in the pathophysiology of estrogen action

My name is Karthik Yadav Janga and I am currently working as Research Scientist in Novel Drug Delivery team at Bayer Pharmaceuticals (USA). I am writing this email in order to volunteer for joining the editorial board member and peer reviewer for your prestigious journal. I have published 23 research articles in renowned journals such as European Journal of Pharmaceutics and Biopharmaceutics and International Journal of Pharmaceutics etc, with over 273 citations. 8+ (academic and industrial) years research experiences in the field of pharmaceutics and drug delivery.

Research Interest: Drug delivery of NCEs, Protein, Peptides, Monoclonal antibodies

Grants: Research Scholar in NIH R01 grant

URL: https://scholar.google.com/citations?user=xZ4Z2wkAAAAJ&hl=en

List of Publications:

1.  Lipid nanoparticles of zaleplon for improved oral delivery by Box-Behnken design: optimization, in vitro and in vivo evaluation. N Dudhipala, KY Janga. Drug Dev Ind Pharm. 2017; 43(7): 1205-1214.

2.  Biopharmaceutical and Preclinical Studies of Zaleplon as Semisolid Dispersions with Self-emulsifying Lipid Surfactants for Oral Delivery. N Dudhipala, A Narala, D Suram, KY Janga. IJPSN. 2016; 9(1): 3102-3111. (Best Paper of the Year Award)

3.  Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. DR Komala, KY Janga, R Jukanti, S Bandari, M Vijayagopal. J Drug Deliv Sci Technol. 2015; 30(A): 232-241. Main Author

4.  Gellan gum based sol-to-gel transforming system of natamycin transfersomes improves topical ocular delivery. KY Janga, A Tatke, N Dudhipala, SP Balguri, MM Ibrahim, DN Maria, MM Jablonski, S Majumdar. JPET. Mar 14, 2019. DOI: https://doi.org/10.1124/jpet.119.256446

5.  Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation. KY Janga, A Tatke, SP Balguri, SP Lamichanne, MM Ibrahim, DN Maria, MM Jablonski, S Majumdar. Artif Cells Nanomed Biotechnol. 2018; 46(1): 1039-1050.

6.  Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improve the ocular penetration of loperamide. KY Janga, A Tatke, S Shukla, SP Lamichhane, B Avula, X Wang, MM Jablonski, IA Khan, S Majumdar. J Pharm Sci. 2018; 107(8): 2128-2135.

7.  Photostability Issues in Pharmaceutical Dosage Forms and Photostabilization. KY Janga, T King, N Ji, S Sarabu, G Shadambikar, S Sawant, P Xu, MA Repka, SN Murthy. AAPS PharmSciTech. 2018; 19(1): 48-59.

8.  P-glycoprotein restricts ocular penetration of loperamide across the blood-ocular barriers: a comparative study in Mdr1a knock-out and wild type sprague dawley rats. A Tatke, KY Janga, B Avula, X Wang, MM Jablonski, IA Khan, S Majumdar. AAPS PharmSciTech. 2018; 19(4): 1662-1671.

9.  In situ absorption and relative bioavailability studies of zaleplon loaded self-nanoemulsifying powders. KY Janga, R Jukanti, S Sunkavalli, A Velpula, S Bandari, P Kandadi, PR Veerareddy. J Microencapsul. 2013; 30(2): 161-172.

10.  Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge. KY Janga, R Jukanti, A Velpula, S Sunkavalli, S Bandari, P Kandadi, PR Veerareddy. Eur J Pharm Biopharm. 2012; 80(2): 347-357.

11.  Melt-cast films significantly enhance triamcinolone acetonide delivery to the deeper ocular tissues. A Tatke, N Dudhipala, KY Janga, B Soneta, B Avula, S Majumdar. Pharmaceutics. 2019; 11(4): 158.

12.  In situ gel of triamcinolone acetonide-loaded solid lipid nanoparticles for improved topical ocular delivery: Tear kinetics and ocular disposition studies. A Tatke, N Dudhipala, KY Janga, SP Balguri, B Avula, M Jablonski, S Majumdar. Nanomaterials. 2019; 9(1): 33.

13. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation. N Dudhipala, KY Janga, T Gorre. Artif Cells Nanomed Biotechnol. 2018; 46(2): 616-625.

14. Micronized zaleplon delivery via orodispersible film and orodispersible tablets. P Manda, C Popescu, A Juluri, KY Janga, PR Kakulamarri, S Narishetty, SN Murthy, MA Repka. AAPS PharmSciTech. 2018; 19(3): 1358-1366.

15. Melt-cast noninvasive ocular inserts for posterior segment drug delivery. SP Balguri, GR Adelli, A Tatke, KY Janga, P Bhagav, S Majumdar. J Pharm Sci. 2017;106(12): 3515-3523.

16. Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol. SP Balguri, GR Adelli, KY Janga, P Bhagav, S Majumdar. Int J Pharm. 2017; 529(1-2): 32-43.

17. Preparation and characterization of docetaxel self-nanoemulsifying powders (SNEPs): A strategy for improved oral delivery. S Sunkavalli, BB Eedara, KY Janga, A Velpula, R Jukanti, S Bandari. KOREAN J CHEM ENG. 2016; 33(3): 1115–1124.

18. Amoxycillin trihydrate floating-bioadhesive drug delivery system for eradication of Helicobacter pylori: Preparation, in vitro and ex vivo evaluation. N Dudhipala, A Narala, KY Janga, R Bomma. J Bioequiv Availab. 2016; 8(3): 118-124.

19. Enhanced dissolution efficiency of zaleplon solid dispersions via modified β-cyclodextrin molecular inclusion complexes. C Popescu, P Manda, A Juluri, KY Janga, M Cidda, SN Murthy. J. Pharm Pharm Scien. 2015; 1(1): 12-21.

20. Proliposome powders for enhanced intestinal absorption and bioavailability of raloxifene hydrochloride: effect of surface charge. A Velpula, R Jukanti, KY Janga, S Sunkavalli, S Bandari, P Kandadi, PR Veerareddy. Drug Dev Ind Pharm. 2013; 39(12): 1895-1906.

21. Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid lipid nanoparticles. M Burraa, R Jukanti, KY Janga, S Sunkavalli, A Velpula, S Ampati, KN Jayaveera. ADV POWDER TECHNOL. 2013; 24(1): 393-402.

22. Development and characterization of ramipril loaded Solid self nanoemulsifying drug delivery system (SNEDDS) for improved oral delivery of lipophilic drugs. M Kasturi, S Agrawal, KY Janga. IJPBA. 2015; 6(6): 10-17.

23. Self nano emulsifying drug delivery system of ramipril: formulation and in vitro evaluation. M Kasturi, S Agrawal, KY Janga. Int J Pharm Pharm Sci. 2016; 8(4): 291-296.

He is a member of the European Society for Paediatric Endocrinology (ESPE) and the Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), among others. research focus is the investigation of the pathophysiology of insulin resistance during childhood growth and development, the metabolic syndrome, and endocrinological disorders in children with rare diseases and genetic syndromes and disorders.

Research Interest: Andrological Sciences.

Research Interest: Sports Injuries.,Sports and Health.,Sarcopenia.,Sports nutrition

Research Interest: The nature of memory retained in the uterine myometrium that is responsible for recurrent loss of pregnancy ii. Regulation of small gproteins by oxidative and endoplasmic stress responses in pregnancies complicated by diabetes mellitus

Research Interest: Angiotensin II effects on renal dopamine metabolism using in vitro models and different techniques like pharmacological approaches, kinetic studies, enzymatic activities and radiolabel markers. For my postdoctoral work, I expanded my research area and studied the relationship between atrial natriuretic peptide and renal dopamine system and its impact on sodium handling. For this purpose we employed an in vivo model to evaluate this interaction on urinary parameters and used molecular techniques to demonstrate the involvement of different tubular transports

Research Interest: Have expertise in the field of Endocrine Physiology and Metabolism, more specifically working with metabolic programming in critical stages of life development and its consequences on the body weight composition and pancreatic islets function. Actually, the field of studies is undernutrition in early life and the development of obesity and type 2 diabetes later in life.

Research Interest: Urologia, Urological Surgery, Andrologia, Clinical Medicine

Research Interest: Menopause and oestrogen replacement therapy (ERT) Metabolic syndrome and metabolic effects of estrogens Phytoestrogens, SERM and Endocrine Disruptors Polycystic ovary syndrome (PCOS) Polymorphisms of the oestrogen receptor geneAnti-inflammatory and anti-atherogenic properties of estrogens

In 2009, graduated from Tianjin Medical University with a Ph.D. in immunology. In the same year, began to work in the Institute of Ophthalmology of Tianjin Medical University, where worked as a basic researcher. In 2012, went to Germany for a one-year postdoctoral research. Up to now, has undertaken and completed three national and provincial-level projects, and published a total of 66 research papers.

Research Interest:

PSF signalling pathway

Ocular neovascularization disease

Experimental autoimmune uveitis (EAU)

Mesenchymal stem cell therapy

Dentritic cells maturation and migration

Grants:

•  as a project principal: PTB-associated splicing factor (PSF) functions as a repressor of HIF-1α-mediated VEGF gene transcription by recruitment of Hakai. (NSFC Granted NO. 81570872,2016-2019)

•  as a project principal: the molecular mechanism of transcriptional inhibitor PSF suppress Human retinal microvessal endothelial cells proliferation with IGF-1 stimulation. (NSFC Granted NO. 31100991,2012-2014)

•  as the participant :Identification the miRNAs related with the differentiation of ESCs into RPE cells and theit effect on JUN passway. (NSFC Granted NO. 30973255, 2011-2013)

List of Publications:

1.  Dong, L., Zhang, X., Fu, X., Zhang, X., Gao, X., Zhu, M., . . . Yang, J. (2011). PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem, 286(5), 3451-3459. doi:10.1074/jbc.M110.168377（co-first author）

2.  Liu, X., Dong, L., Zhang, X., Wang, B., Wang, X., Li, H., . . . Yang, J. (2011). Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS). Cell Mol Immunol, 8(1), 88-91. doi:10.1038/cmi.2010.47（co-first author）

3.  WB, L., MW, M., LJ, D., F, W., LX, C., biology, L. X. J. C., & therapy. (2011). MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. 12(6), 477-483. (co-author)

4.  Li WB, Z. Y., Lu ZY,  Dong LJ,  Wang FE,  Dong R,  Li XR. (2012). Development of retinal pigment epi thelium from human parthenogenetic embryonic stem cells and microRNA signature. Invest. Ophthalmol. Vis. Sci., 53(9). doi:10.1167/iovs.12-8303  (co-author)

5.  LJ, Z., Y, Z., LJ, D., & ophthalmology, L. X. J. C. j. o. (2012). [Expression and function of microRNA in the eye]. 48(12), 1136-1140. (co-author)

6.  Tian, F., Dong, L., Zhou, Y., Shao, Y., Li, W., Zhang, H., & Wang, F. (2014). Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. Int J Mol Sci, 15(8), 13833-13848. doi:10.3390/ijms150813833（co-first author）

7.   Wei, R., Dong, L., Xiao, Q., Sun, D., Li, X., & Nian, H. (2014). Engagement of Toll-like receptor 2 enhances interleukin (IL)-17(+) autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells. Clin Exp Immunol, 178(2), 353-363. doi:10.1111/cei.12405（co-first author）

8.  Zhang, L., Dong, L., Liu, X., Jiang, Y., Zhang, L., Zhang, X., . . . Zhang, Y. (2014). alpha-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One, 9(4), e93433. doi:10.1371/journal.pone.0093433 (co-author)

9.  Zhang, L., Zheng, H., Shao, H., Nian, H., Zhang, Y., Bai, L., . . . Zhang, X. (2014). Long-term therapeutic effects of mesenchymal stem cells compared to dexamethasone on recurrent experimental autoimmune uveitis of rats. Invest Ophthalmol Vis Sci, 55(9), 5561-5571. doi:10.1167/iovs.14-14788 (co-author)

10.  T, L., L, Z., B, Z., L, X., J, L., L, D., & reports, H. Y. J. O. (2015). Establishment and characterization of a cell line from human adenoid cystic carcinoma of the lacrimal glands and a nude mouse transplantable model. 33(6), 2797-2806. (co-author)

11.  Dong, L., Nian, H., Shao, Y., Zhang, Y., Li, Q., Yi, Y., . . . Li, X. (2015). PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell Tissue Res, 360(2), 233-243. doi:10.1007/s00441-014-2104-5 (the first author)

12.  Shao, Y., Dong, L. J., Zhang, Y., Liu, H., Hu, B. J., Liu, J. P., & Li, X. R. (2015). Surgical induced astigmatism correlated with corneal pachymetry and intraocular pressure: transconjunctival sutureless 23-gauge versus 20-gauge sutured vitrectomy in diabetes mellitus. Int J Ophthalmol, 8(3), 528-533. doi:10.3980/j.issn.2222-3959.2015.03.16 （co-first author）

13.  Y, S., C, S., JT, W., B, D., LJ, D., AH, L., . . . medicine, e. (2015). Temporal and spatial changes in VEGF, αA- and αB-crystallin expression in a mouse model of oxygen-induced retinopathy. 8(3), 3349-3359. (co-author)

14.  PT, Z., LJ, Z., H, S., LL, B., B, Y., C, S., . . . ophthalmology, Z. X. J. I. j. o. (2016). Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. 9(10), 1381-1389. (co-author)

15.  W, L., L, D., M, M., B, H., Z, L., X, L., . . . therapy. (2016). Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration. 10(undefined), 3415-3423.（co-first author）

16.  X, C., H, S., Y, Z., Q, X., C, S., L, D., . . . development. (2016). CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses. 25(4), 337-346. (co-author)

17.  H, T., LY, H., F, T., LJ, D., & ophthalmology, Z. H. J. C. j. o. (2017). [Effects of SMP-30 overexpression on apoptosis of human lens epithelial cells induced by ultraviolet B irradiation]. 53(11), 835-841. (co-author)

18.  L, B., H, S., H, W., Z, Z., C, S., L, D., . . . reports, Z. X. J. S. (2017). Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. 7(1), 4323. (co-author)

19.  X, W., Y, Z., L, Z., R, W., & vision, D. L. J. M. (2017). Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery. 23(undefined), 275-285. (co-author)

20.  L, D., X, C., H, S., L, B., X, L., & medicine, Z. X. J. C. m. (2018). Mesenchymal Stem Cells Inhibited Dendritic Cells Via the Regulation of STAT1 and STAT6 Phosphorylation in Experimental Autoimmune Uveitis. 17(7), 478-487. (the first author)

21.  T, M., LJ, D., XL, D., R, N., & ophthalmology, H. B. J. I. j. o. (2018). Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy. 11(9), 1550-1554.

22.  X, X., L, H., Y, L., X, L., R, S., X, L., & research, D. L. J. C. e. (2019). DL-3-n-butylphthalide Protected Retinal Müller Cells Dysfunction from Oxidative Stress. undefined(undefined), 1-9. (co-author)

23.  Y, S., LJ, D., Y, T., J, C., X, L., Q, C., . . . metabolism. (2019). miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy. 316(3), E443-E452. （co-first author）

24.  G, S., R, H., L, Z., X, S., K, H., L, D., . . . failure, K. Y. J. R. (2019). The effect of hemodialysis on ocular changes in patients with the end-stage renal disease. 41(1), 629-635. (co-author)

Research Interest: Diabetes type 1 and 2, insulin resistance, skeletela muscle, cardiovascular risk in diabetes