International Journal of Clinical Endocrinology and Metabolism Submit Manuscript

    Introduction

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    • Review ProcessDouble Blind
      • Publication lead time3 - 4 weeks
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      • Submission ChargesNo
      • Waiver policy for APCYes
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    • Articles digitally archived in PORTICO
    • Permanent article identifierDOI (Digital Object Identifier) We provide DOI to all published papers to facilitate higher citation and classification of articles.
      Peertechz Publisher ID: 10.17352
    • Type of LicenseCreative Commons
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    Editor-in-Chief

    Malgorzata Gabriela WASNIEWSKA

    Malgorzata Gabriela WASNIEWSKA
    University of Messina, Italy
    Email: [email protected]
    Tel: +393286522425
    Fax: +390902212134

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    Executive Editors

    Sze May Ng
    Consultant Paaediatric Endocrinologist , Honorary Senior Lecturer
    Southport and Ormskirk Hospitals NHS Trust
    University of Liverpool
    United Kingdom
    IJCEM

    Dr May Ng MBBS (Hons) FHEA FRCPCH MSc LLM PhD

    Dr May Ng holds a dual accreditation specialist qualification in General Paediatrics and Paediatric Endocrinology & Diabetes. She is based in Southport and Ormskirk NHS Trust and is the Associate Medical Director. She was previously Clinical Director for Paediatrics from 2012-2016.  She has an Honorary Senior Lecturer position at the Institute of Translational Medicine, University of Liverpool. She completed her undergraduate degree under full scholarship in Sydney, Australia and undertook her paediatric training in Australia and in the United Kingdom (UK). She was the recipient of the UK Medical Research Council Fellowship in 2006 and completed further training to obtain a Masters and PhD degree in paediatric endocrinology and diabetes. Dr Ng also holds a Master of Laws degree and is active in medicolegal work.

    Dr Ng has held over £300,000 in research grants and is an active researcher in paediatric endocrinology and diabetes. She has produced a book chapter and over 100+ publications (50 peer reviewed research papers, 45 as first/senior author) including three Cochrane reviews and has presented at more than 100+ scientific meetings.

    Research Interest: puberty, thyroid, diabetes , adrenal

    URL: www.paedsdoc.co.uk

    PROFESSIONAL MEMBERSHIPS AND ROLES:

    Fellow of the Royal College of Paediatrics and Child Health (FRCPCH)

    Fellow of the Higher Education Academy (FHEA)

    Member of the European Society of Paediatric Endocrinology (ESPE)

    Committee member of European Society of Paediatric Endocrinology Online Learning

    Member of the National Institute of Clinical Excellence (NICE) Adoption and Impact Programme Reference Panel

    Member of the National Steering Group for Children and Young People’s Diabetes Peer Review

    Diabetes Officer of the British Society of Paediatric Endocrinology and Diabetes (BSPED)

    Assessor for the Royal College of Paediatrics and Child Health ST7/START

    Committee Member of the RCPCH Paediatricians in Medical Management

    RCPCH CSAC Training Advisor for Endocrinology and Diabetes


    PROFESSIONAL QUALIFICATIONS:

    CCST, Certificate of Completion of Specialist Training: (1) General Paediatrics and (2) Paediatric Endocrinology and Diabetes, General Medical Council UK

    FRCPCH, Royal College of Paediatrics and Child Health, UK

    DCH, Royal College of Paediatrics and Child Health, UK

    FHEA, Fellow of the Higher Education Academy, UK

    MBBS (Honours) University of Sydney, Australia

    Master of Medical Science (Child Health, Diabetes and Endocrinology) University of Liverpool

    PhD (Child Health) University of Liverpool

    Master in Laws , University of Liverpool</xml> <

    Grant details:

    Winner of 2015 Diabetes Quality in Care (QiC) award
    Finalist Commended 2017 Diabetes Team of the year Diabetes Quality in Care (QiC) award
    Pride Awards 2015 Team of the Year Southport & Ormskirk NHS Trust
    Highly Commended Diabetes Team of the Year 2015 BMJ awards
    Finalist HSJ Clinical Leader of the year 2015
    Finalist in the UK Asian Woman of Achievement Award
    Newborn Appeal Grant 2011
    Best Research Abstract Award 2010 BSPED UK
    Newborn Appeal Grant 2007
    MRC Fellowship 2006 Medical Research Council, UK
    University Prize for Paediatrics,    University of Sydney, Australia

    Number of Publications: 50

    1.    Ng SM, Turner MA, Avula S. Ultrasound measurements of thyroid gland volume at 36 weeks corrected gestational age in extreme preterm infants born before 28 weeks gestation. European Thyroid Journal 2017.

    2.    Apperley L, Ng SM. Socioeconomic Deprivation, Household Education and Employment are Associated With Increased Hospital Admissions and Poor Glycemic Control in Children With Type 1 Diabetes Mellitus. Review of Diabetic Studies 2017

    3.    Ng SM. Digital Footprints: Steps towards transformation in paediatric diabetes. Journal of MHealth 2017, March ow.ly/g6Um30aYCZU

    4.    Ng SM, Stepien K. Glucocorticoid replacement regimens in the treatment of 21-hydroxylase deficiency congenital adrenal hyperplasia (Protocol) published Cochrane Database of Systematic Reviews 2017, Issue 1. Art. No CD012517. DOI: 10.1002/14651858.CD012517

    5.    Ng SM, Edge J. Hyperglycaemic Hyperosmolar State (HHS) in children: A practical guide to management. Paediatrics and Child Health Journal 2017 http://dx.doi.org/10.1016/j.paed.2017.01.002

    6.    Ng SM, Soni A, Didi M. Neonatal Pituitary-Thyroid Axis Dysregulation with Combined Thyroid Hormone and Thyrotropin Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism. J Neonatal Biol 2016 5:4 DOI: 10.4172/2167-0897.1000243

    7.     Ng SM, Agwu JC, Dwan K. A systematic review and meta-analysis of Synacthen tests for assessing hypothalamic-pituitary-adrenal insufficiency in children. Arch Dis Child 2016 :1–7. doi:10.1136/archdischild-2015-308925

    8.    Ng SM, Turner M. The Importance of Risk Stratification and Management of Newborn Babies of Women with a History of Graves’ disease. Int J Clin Endocrinol Metab 2016, 2(1): 001-004
    9.    Soni A, Agwu JC, Kershaw M, Edge J, Wright N, Ng SM. Management of children with type 1 diabetes during illness: a national survey. Postgrad Med J 2015 doi:10.1136/postgradmedj-2015-133786

    10.    Ng SM, Vizard M. The great enabler: how technology is helping to improve patient outcomes in paediatric diabetes. British Journal of Diabetes and Vascular Disease 2015;15:86-88

    11.    Soni A, Ng SM. Type 1 and Type 2 diabetes in children and young people: updated NICE guidance. Practical Diabetes 2015;32:281-282

    12.    Ng SM. Improving patient outcomes with technology and social media in paediatric diabetes. BMJ Quality Improvement Reports 2015; 4(1) DOI:10.1136/bmjquality.u209396.w3846 (1)

    13.    Ng SM, Watson G, Turner MA, Newland P and Weindling AM. Do maternal factors influence neonatal thyroid status in the extreme premature infant? The Journal of Maternal-Fetal & Neonatal Medicine 2014:26:1-11.

    14.    Agwu C, Ng SM, Edge DA, Wright. Care of children and young people with diabetes who require surgery. Diabetes Care for Children and Young People 2014:3:106-110

    15.    Ng SM, Soni A. Intensive diabetes management and goal setting are key aspects of improving metabolic control in children and young people with Type 1 diabetes mellitus. World Journal of Diabetes 2014: 5(6): 877-881 DOI: http://dx.doi. org/10.4239/wjd.v5.i6.877

    16.    Ng SM, Finnigan L, Connellan L, Caitriona Kerinan, Coward S. Improving paediatric diabetes care with the use of an integrated paediatric electronic diabetes information management system and routine uploading of blood glucose meters and insulin pumps in outpatient clinics. Archive of Disease in Childhood 2014; 99:1059 doi:10.1136/archdischild-2014-307021

    17.    Ng SM, Mariguddi S, Coward S, Middleton H. Successful implementation of a paediatric community home nursing service as a model of service delivery in acute paediatric care. British Journal of Nursing 2014: 23 (4):209-212.

    18.    Ng SM, Turner MA, Watson G, Victor S, Isherwood DM, Newland P, Didi M and Weindling AM. Is dopamine an iatrogenic disruptor of thyroid and cortisol function in the extremely premature infant? Advances in Endocrinology 2014; DOI:http://dx.doi.org/10.1155/2014/973184

    19.    Soni A, Shaw EJ, Natarajan A, Ng SM. Children with Type 1 Diabetes mellitus developing concurrent autoimmune disease are not at risk of worsening metabolic control or growth impairment. Practical Diabetes 2014: 31(6):243-246

    20.    Ng SM, Turner MA, Didi M, Parkes L, Tietze A, Atkinson J, Sluming V and Weindling AM. Effect of thyroxine on brain microstructure in extremely premature babies: magnetic resonance imaging findings from the TIPIT study. Pediatric Radiology 2014:44 (8):987-96

    21.    Ng SM, Balmuri S. Review of insulin treatment in stress related hyperglycaemia in children without pre-existing diabetes. Acta Paediatrica 2013 doi:10.1111/apa.12442
    22.    Ng SM, Turner MA, Victor S, M Didi, C Gamble, D Manning, R Gupta, P Settle. P Newland and Weindling AM. An explanatory randomised placebo-controlled trial of thyroxine supplementation in extreme preterm Infants < 28>
    23.    Murphy A, Martin P, Jukka C, Menon A, Ng SM. Recurrent primary paediatric herpetic whitlow of the big toe. BMJ Case Reports 2013 doi:10.1136/bcr-2013-008598

    24.    Murphy C and Ng SM. Institution of multiple daily insulin regimen compared with twice daily pre-mixed insulin regimen for children with Type 1 Diabetes Mellitus. American Journal of Clinical Medicine Research 2013  1 (1). doi: 10.12691/ajcmr-1-1-2

    25.    Ng SM, Drury JA, Turner MA, M Didi, Victor S, Paul Newland, Weindling AM. A Novel Method of Collection of Saliva for Estimation of Steroid Levels in Extremely Premature Infants. Acta Paediatrica 2013:102 (4): 356-9

    26.    Gangadharan A, Hanumanthaiah H, Ng SM.  The Use of Iodine as First Line Therapy in Graves' Disease Complicated with Neutropenia at First Presentation in a Paediatric Patient. British Journal of Medicine and Medical Research, 3(2): 324-328, 2013

    27.    Hanumanthaiah H, Gangadharan A, Ng SM. Continuous insulin infusion therapy for acute stress hyperglycemia secondary to asthma exacerbation in a paediatric patient. Journal of Diabetes Research and Clinical Metabolism 2012: http://dx.doi.org/10.7243/2050-0866-1-19

    28.    Ng SM, Wong SC, Chakkrapani E, Rahman F, Newland P, Isherwood DM, Didi M.  Multivariate analysis of factors that affect neonatal screening thyrdois stimulating hormone. Journal of Pediatric Endocrinology and Metabolism 2011, 24: 727-732

    29.    Hussain M, Cheri J, Khalid M, Matouk Z, Ng SM, Chanderasekaran S, Didi M, Blair J. Growth monitoring still has a place in selected populations of children. BMJ Case Reports 2011; doi:10.1136/bcr.01.2010.2640

    30.    Ng SM, Weindling MA. The impact of networks on clinical trials in the United Kingdom . Trials 2009, 10:100

    31.    Ng SM, Turner MA, Gamble C, M Didi, Victor S, Malamateniou C, Parkes L, Tietze A, Gregory L,Sluming V, Abernethy L and Weindling AM. TIPIT: A Randomised Controlled Trial of Thyroxine in Preterm Infants under 28 weeks Gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography Protocol. BMC Pediatrics 2008, 8:26

    32.    Ng SM. Hypothyroxinemia of prematurity: cause, diagnosis and management. Expert Review of Endocrinology & Metabolism 2008, 3: 453-462

    33.    Ng SM, Dhullipala A, Weindling AM. High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism. Cochrane Database of Systemic Reviews 2008, Issue 1

    34.    Ng SM, Turner MA, Gamble, Didi M, Victor S, Weindling AM. TIPIT: A Randomised controlled trial of thyroxine in preterm infants born under 28 weeks gestation. Trials 2008, 9: 17

    35.    Ng SM, Wong SC, Isherwood DM, Didi M. Biochemical severity of thyroid ectopia in congenital hypothyroidism demonstrates sexual dimorphism. European Journal of Endocrinology 2007, 156: 49-53

    36.    Ng SM, Wong SC, Chakkrapani E, Rahman F, Newland P, Isherwood DM, Didi M.  There is a delay in screening premature infants for congenital hypoithyroidism. Archives of Disease in Childhood Fetal Neonatal Ed 2006, 91: F465-466

    37.    Ng SM, May JE, Emmerson AJB. Continuous insulin infusion in hyperglycemic ELBW infants: An evaluation of treatment response. Biology of the Neonate 2005, 4: 269-272

    38.    Ng SM, Kumar Y, Cody D, Didi M and Smith CS. The gonadotrophins response to GnRH test is not a predictor of neurological lesion in girls with central precocious puberty. Journal of Pediatric Endocrinology and Metabolism 2005, 18: 849-852

    39.    Ng SM, Wong SC, Isherwood DM, Smith CS, Didi M. Multivariate analysis on factors affecting suppression of thyroid stimulating hormone in treated congenital hypothyroidism. Hormone Research 2004, 20: 245-251

    40.    Wong SC, Ng SM, Didi M. Children with congenital hypothyroidism are at risk of adult obesity due to early adiposity rebound. Clinical Endocrinology 2004, 61: 441-6

    41.    Ng SM, Wong SC, Didi M. Head circumference and linear growth during the first 3 years in treated congenital hypothyroidism in relation to aetiology and initial biochemical severity. Clinical Endocrinology 2004, 61: 155-9

    42.    Chalameau M, Hadjiaathanasiou C, Ng SM, Cassio A, Mul D, Cisternino M, Partsch CJ, Theodoris C, Didi M, Cacciari E, Oostdijk W, Borghesi A, Sippell WG, Breart G, Brauner R. How to select girls with precocious puberty for brain imaging? An evidence based approach: EUROPUB study. A multicentre trial. Journal of Pediatrics 2003, 143: 445-450

    43.    Ng SM, Jones AP. Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Collaboration, Cochrane Library 2003, Issue 2

    44.    Ng SM, Kumar Y, Cody D, Didi M and Smith CS. Cranial MRI scans are indicated in all girls with central precocious puberty. Archives of Disease in Childhood 2003, 88:  414-418

    45.    Cody D, Ng SM, Didi M and Smith CS. The differing outcomes of hyperthyrotropinemia. Journal of Paediatric Endocrinology and Metabolism 2003, 16: 375-378

    46.    Ng SM, Khurana R, Hughes U, Manning D. Is prolonged use of computer games a risk factor for deep venous thrombosis in children? Clinical Medicine 2003, 6: 593-594

    47.    Ng SM, Toh EM and Sherrington CA. Clinical predictors of abnormal computed tomography scans in paediatric head injury. Journal of Paediatrics and Child Health 2002, 38: 388-392

    48.    Ng SM, Ariffin WA, Lin HP, Chan LL and Chin YM. Clinical features and treatment outcome of children with myeloid antigen coexpression in B-lineage acute lymphoblastic leukemia. Journal of Tropical Paediatrics 2000, 46: 73-78

    49.    Ng SM, Lin HP, Ariffin WA, Lam SK and Chan LL. Age, sex, hemoglobin and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol. Journal of Tropical Paediatrics 2000, 46:  338-343

    50.    Ng SM, Ariffin WA, Lin HP and Chan LL. Presenting features and treatment outcome of 78 Malaysian children with neuroblastoma. Southeast Asian Journal of Tropical Medicine and Public Health 1999, 30: 149-153



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    Editorial Board

    Rodrigo Mello Gomes
    Department of Cell Biology and Genetics
    Garden Universitario
    Brazil
    IJCEM

    Research Interest: Obesity and diabetes mainly involving the early stages of life (pregnancy and lactation), research is related to the concept DoHAD (Developmental Origins of Health and Disease, areas of metabolic diseases and physical exercise.

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    Juan de Dios Beas Jimenez
    Andalusian Center of Sports Medicine
    Spain
    IJCEM

    Research Interest: Sports Injuries.,Sports and Health.,Sarcopenia.,Sports nutrition

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    Anna Ciampolillo
    Department of Emergency and Organ Transplantation
    University of Bari
    Italy
    IJCEM

    Research Interest: Role of autoimmunity in the pathogenesis of thyroid diseases. Growth factors and thyroid cancer. Prevention of endemic goiter

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    Karthik Yadav Janga
    Research Scientist
    Pharmaceutics and Drug Delivery, Formulation R&D
    University of Mississippi
    United States
    IJCEM

    My name is Karthik Yadav Janga and I am currently working as Research Scientist in Novel Drug Delivery team at Bayer Pharmaceuticals (USA). I am writing this email in order to volunteer for joining the editorial board member and peer reviewer for your prestigious journal. I have published 23 research articles in renowned journals such as European Journal of Pharmaceutics and Biopharmaceutics and International Journal of Pharmaceutics etc, with over 273 citations. 8+ (academic and industrial) years research experiences in the field of pharmaceutics and drug delivery.

    Research Interest: Drug delivery of NCEs, Protein, Peptides, Monoclonal antibodies

    Grants: Research Scholar in NIH R01 grant

    URL: https://scholar.google.com/citations?user=xZ4Z2wkAAAAJ&hl=en

    List of Publications:

    1.  Lipid nanoparticles of zaleplon for improved oral delivery by Box-Behnken design: optimization, in vitro and in vivo evaluation. N Dudhipala, KY Janga. Drug Dev Ind Pharm. 2017; 43(7): 1205-1214.

    2.  Biopharmaceutical and Preclinical Studies of Zaleplon as Semisolid Dispersions with Self-emulsifying Lipid Surfactants for Oral Delivery. N Dudhipala, A Narala, D Suram, KY Janga. IJPSN. 2016; 9(1): 3102-3111. (Best Paper of the Year Award)

    3.  Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. DR Komala, KY Janga, R Jukanti, S Bandari, M Vijayagopal. J Drug Deliv Sci Technol. 2015; 30(A): 232-241. Main Author

    4.  Gellan gum based sol-to-gel transforming system of natamycin transfersomes improves topical ocular delivery. KY Janga, A Tatke, N Dudhipala, SP Balguri, MM Ibrahim, DN Maria, MM Jablonski, S Majumdar. JPET. Mar 14, 2019. DOI: https://doi.org/10.1124/jpet.119.256446

    5.  Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation. KY Janga, A Tatke, SP Balguri, SP Lamichanne, MM Ibrahim, DN Maria, MM Jablonski, S Majumdar. Artif Cells Nanomed Biotechnol. 2018; 46(1): 1039-1050.

    6.  Retina compatible interactions and effective modulation of blood ocular barrier P-gp activity by third-generation inhibitors improve the ocular penetration of loperamide. KY Janga, A Tatke, S Shukla, SP Lamichhane, B Avula, X Wang, MM Jablonski, IA Khan, S Majumdar. J Pharm Sci. 2018; 107(8): 2128-2135.

    7.  Photostability Issues in Pharmaceutical Dosage Forms and Photostabilization. KY Janga, T King, N Ji, S Sarabu, G Shadambikar, S Sawant, P Xu, MA Repka, SN Murthy. AAPS PharmSciTech. 2018; 19(1): 48-59.

    8.  P-glycoprotein restricts ocular penetration of loperamide across the blood-ocular barriers: a comparative study in Mdr1a knock-out and wild type sprague dawley rats. A Tatke, KY Janga, B Avula, X Wang, MM Jablonski, IA Khan, S Majumdar. AAPS PharmSciTech. 2018; 19(4): 1662-1671.

    9.  In situ absorption and relative bioavailability studies of zaleplon loaded self-nanoemulsifying powders. KY Janga, R Jukanti, S Sunkavalli, A Velpula, S Bandari, P Kandadi, PR Veerareddy. J Microencapsul. 2013; 30(2): 161-172.

    10.  Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge. KY Janga, R Jukanti, A Velpula, S Sunkavalli, S Bandari, P Kandadi, PR Veerareddy. Eur J Pharm Biopharm. 2012; 80(2): 347-357.

    11.  Melt-cast films significantly enhance triamcinolone acetonide delivery to the deeper ocular tissues. A Tatke, N Dudhipala, KY Janga, B Soneta, B Avula, S Majumdar. Pharmaceutics. 2019; 11(4): 158.

    12.  In situ gel of triamcinolone acetonide-loaded solid lipid nanoparticles for improved topical ocular delivery: Tear kinetics and ocular disposition studies. A Tatke, N Dudhipala, KY Janga, SP Balguri, B Avula, M Jablonski, S Majumdar. Nanomaterials. 2019; 9(1): 33.

    13. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation. N Dudhipala, KY Janga, T Gorre. Artif Cells Nanomed Biotechnol. 2018; 46(2): 616-625.

    14. Micronized zaleplon delivery via orodispersible film and orodispersible tablets. P Manda, C Popescu, A Juluri, KY Janga, PR Kakulamarri, S Narishetty, SN Murthy, MA Repka. AAPS PharmSciTech. 2018; 19(3): 1358-1366.

    15. Melt-cast noninvasive ocular inserts for posterior segment drug delivery. SP Balguri, GR Adelli, A Tatke, KY Janga, P Bhagav, S Majumdar. J Pharm Sci. 2017;106(12): 3515-3523.

    16. Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol. SP Balguri, GR Adelli, KY Janga, P Bhagav, S Majumdar. Int J Pharm. 2017; 529(1-2): 32-43.

    17. Preparation and characterization of docetaxel self-nanoemulsifying powders (SNEPs): A strategy for improved oral delivery. S Sunkavalli, BB Eedara, KY Janga, A Velpula, R Jukanti, S Bandari. KOREAN J CHEM ENG. 2016; 33(3): 1115–1124.

    18. Amoxycillin trihydrate floating-bioadhesive drug delivery system for eradication of Helicobacter pylori: Preparation, in vitro and ex vivo evaluation. N Dudhipala, A Narala, KY Janga, R Bomma. J Bioequiv Availab. 2016; 8(3): 118-124.

    19. Enhanced dissolution efficiency of zaleplon solid dispersions via modified β-cyclodextrin molecular inclusion complexes. C Popescu, P Manda, A Juluri, KY Janga, M Cidda, SN Murthy. J. Pharm Pharm Scien. 2015; 1(1): 12-21.

    20. Proliposome powders for enhanced intestinal absorption and bioavailability of raloxifene hydrochloride: effect of surface charge. A Velpula, R Jukanti, KY Janga, S Sunkavalli, S Bandari, P Kandadi, PR Veerareddy. Drug Dev Ind Pharm. 2013; 39(12): 1895-1906.

    21. Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid lipid nanoparticles. M Burraa, R Jukanti, KY Janga, S Sunkavalli, A Velpula, S Ampati, KN Jayaveera. ADV POWDER TECHNOL. 2013; 24(1): 393-402.

    22. Development and characterization of ramipril loaded Solid self nanoemulsifying drug delivery system (SNEDDS) for improved oral delivery of lipophilic drugs. M Kasturi, S Agrawal, KY Janga. IJPBA. 2015; 6(6): 10-17.

    23. Self nano emulsifying drug delivery system of ramipril: formulation and in vitro evaluation. M Kasturi, S Agrawal, KY Janga. Int J Pharm Pharm Sci. 2016; 8(4): 291-296.

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    Terry D
    Health Science Campus
    University of Toledo
    USA
    IJCEM

    Research Interest: My lab focuses on the involvement of the heme oxygenase (HO) system and nuclear receptors in metabolic diseases, which includes obesity and diabetes as well as cancer. The HO system maintains metabolic balance by signaling to biliverdin reductase that produces the antioxidant, bilirubin. My lab looks at the how HO, bilirubin, and nuclear receptors signal for balance in metabolic disorders. We are currently studying how bilirubin can aid the nutrient and lipid sensing nuclear receptors, the PPARs (PPAR alpha, PPAR gamma, and PPAR delta), in the maintenance of metabolic homeostasis. Other nuclear receptors are stress sensing, such as the glucocorticoid receptors (GRalpha and GR beta), which regulate the immune system balance and glucose production during times of stress. Altogether, we look at the PPARs and GRs regulation of the balance of lipids and glucose as well as maintain growth of cancer cells.

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    Wellerson Rodrigo Scarano
    Associate Professor
    Department of Human Embriology
    Sao Paulo State University
    Brazil
    IJCEM

    Research Interest: Environmental toxins and prostate development,  Endocrine disruptors and urogenital development, Carcinogenesis rodent models for prostate cancer, Chemoprevention in rodent models of prostate carcinogenesis and human cancer cells (in vitro) – AKT pathway evaluation, Reproductive Endocrinology and Infertility, Effects of endocrine disruptors in human Sertoli cells (in vitro) with focus in adhesion molecules, AR pathway and DNA methylation

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    Xinfu Guan
    Assistant Professor
    Departments of Pediatrics and Medicine
    Baylor College of Medicine
    USA
    IJCEM

    Research Interest: My research interests are to reveal the functional relevance of glucagon-like peptides (GLP-1/2) and receptors in the control of energy balance and glucose homeostasis

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    Shu-Pin Huang
    Professor
    Department of Urology
    Kaohsiung Medical University and Hospital
    Taiwan
    IJCEM

    Research Interest: Prostate Cancer, Molecular Epidemiology, Pharmacogenomic studies, Metabolic syndrome, Endocrine-Related Cancer, Urolithiasis, Andrology, Male Erectile dysfunction

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    Angelos Kyriacou
    Department of Endocrinology and Diabetes
    Salford Royal Foundation Trust
    UK
    IJCEM

    Research Interest: Thyroid disease and in particular thyroid nodules and thyroid cancer, as well as postgraduate medical education..

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    GianLuca Colussi
    Department of Experimental and Clinical Medical Sciences
    University of Udine
    Italy
    IJCEM

    Research Interest: His particular interests are in clinical research methodology, data science, and genomic medicine, also having published, as co-author, several papers in scientific journals such as JAMA, Archives of Internal Medicine, Hypertension, Diabetes Care, Journal of Clinical Endocrinology and Metabolism

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    Beata Ewa Pyrzak
    Professor
    Department of Paediatric and Endocrinology
    Mediacal University of Warsaw
    Poland
    IJCEM

    Research Interest: Endocrinology, diabetes, obesity, genetics, children

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    Efstratios Moralidis
    Department of Nuclear Medicine
    Aristotle University Medical School
    Greece
    IJCEM

    Research Interest: An ongoing study on the assessment of renal function in the course of diabetes mellitus

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    RK Dubey
    Department of Reproductive Endocrinology
    University Hospital Zurich
    Switzerland
    IJCEM

    Research Interest: Role of Sex Hormones in Various Pathophysiologies with specific relevance to Women’s Health,role of hormone metabolism in the pathophysiology of estrogen action

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    Dominik Rachon
    Head
    Department of Clinical and Experimental Endocrinology
    Medical University Of Gdansk
    Poland
    IJCEM

    Research Interest: Menopause and oestrogen replacement therapy (ERT) Metabolic syndrome and metabolic effects of estrogens Phytoestrogens, SERM and Endocrine Disruptors Polycystic ovary syndrome (PCOS) Polymorphisms of the oestrogen receptor geneAnti-inflammatory and anti-atherogenic properties of estrogens

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    Janos Szolcsanyi
    Department of Pharmacology
    University of Pecs
    Hungary
    IJCEM

    Research Interest: Physiology and pharmacology of nociceptors by means of capsaicin to open new horizons for development nociceptor targeted analgesic/anti-inflammatory agents and to reveal sensory-efferent dual functions of capsaicin-sensitive nociceptors

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    Does Testosterone Replacement Therapy Prevent Bone Fractures in Hypogonadal Men?

    DOI Logo 10.17352/ijcem.000062

    Published On: November 12, 2024 | Pages: 018 - 019

    Author(s): Nilson Marquardt Filho and Carlos Teodósio Da Ros*

    ORCID Logo  0000-0002-4768-7239

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    DOI Logo 10.17352/ijcem.000061

    Published On: September 24, 2024 | Pages: 014 - 017

    Author(s): Nasir A M Al-Jurayyan*
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    Relationship of insulin resistance with microvascular and macrovascular complications, death rate and other factors in patients with type 2 diabetes: A case-control study

    DOI Logo 10.17352/ijcem.000060

    Published On: July 04, 2024 | Pages: 006 - 013

    Author(s): Gabrielė Čypaitė, Diana Šimonienė* and Emilė Rudminaitė

    ORCID Logo  0000-0002-1841-9147

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    Exploring the potential of thyroid hormone therapy: Recent advancements and controversies

    DOI Logo 10.17352/ijcem.000059

    Published On: June 29, 2024 | Pages: 001 - 005

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    ORCID Logo  0000-0002-6151-5687

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    Investigating polymorphisms in genes encoding TGF-β1, IL-10, and IL-6 and their associations with type 1 diabetes mellitus

    DOI Logo 10.17352/ijcem.000058

    Published On: October 20, 2023 | Pages: 019 - 025

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    ORCID Logo  0000-0002-2423-9353

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    DOI Logo 10.17352/ijcem.000057

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    ORCID Logo  0000-0003-0229-5562

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    DOI Logo 10.17352/ijcem.000056

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    DOI Logo 10.17352/ijcem.000055

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    DOI Logo 10.17352/ijcem.000054

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    DOI Logo 10.17352/ijcem.000053

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    ORCID Logo  0000-0002-6151-5687

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