Research Interest: Deep Specialization in Research Involve; Obesity and Associated Disorder, Its Mechanism and Treatment. Metabolic Syndrome-Food Additives and Its Effect on the Bodyorgans. Also the Biochemical, Oxidative Stress and Advanced Biomarkers in Health and Diseases. Recently Involved in Nanomedical Materials as Antioxidant for Health Maintainance.

Research Interest: He Also Conducted Basic Research in Regard to the Investigation of the Role of Immunological Aspects in Kidney Diseases Including Nephritic Syndrome and Diabetic Nephropathy.

Research Interest: Medicinal Herbs, Behavioral Pharmacology, Neurodegeneration, Neurotransmitters, Neuroscience, Diabetes, Inflammation

Research Interest: Her Clinical and Research Interest Focuses on Diabetes Management, Cardiovascular Risk, Flow Cytometry-Based Study of Endothelial Dysfunction, Novel Therapy for Type 2 Diabetes, Clinical Nutrition and Mediterranean Diet

China Diabetes Impact Study is funded by IDF and technically supported by Division of Diabetes Translation of CDC. It is a follow-up study of China National Diabetes and Metabolic Disorder Study. A total of 12 study sites participated in the China Diabetes Impact Study. I am the national program coordinator and the investigator of Beijing study site. All study participants with DM, NDM and IGR were interviewed and collected information about their health care service use, medical expenditure, etc. 

Research Interest: Cardiovascular diseases, Endothelial function, Hypertension, Diabetes, Renin-angiotensin-system

Lawrence Lavery is a Professor in the Department of Plastic Surgery, as well as Director of Clinical Research in the Department of Plastic Surgery, at the University of Texas Southwestern Medical Center, Dallas, TX.  His research group has published 210 peer reviewed papers and has received extramural funding from the Veterans Administration, the National Institute of Health, the Agency for Healthcare Research and Quality, the American Diabetes Association, and the American College of Foot and Ankle Surgeons. 

Research Interest: Diabetes, Ulcers, Infections, Neuropathy and Osteomyelities

Grants: Supporting with number of grants

List of Publications:
1.    Lavery LA, Oz OK, Bhavan K, Wukich DK.  Diabetic Foot Syndrom in the Twenty-First Century.  Clin Podiatr Med Surg. 2019 July; 3, 355-359.
2.    Kim, PJ, Attinger CE, Orgill D, Galiano RD, Steinberg JS, Evans KK, Lavery LA.  Complex Lower Extremity Wound in the Complex Host:  Results from a Multicenter Registry.  Plastic and Reconstructive Surgery-Global. 2019 Apr.  Epub ahead of print.
3.    Ahn J, Raspovic KM, Liu GT, Lavery LA, La Fontaine J, Nakonezny PA, Wukich, DK.  Lower Extremity Necrotizing Fasciitis in Diabetic and Nondiabetic Patients:  Mortality and Amputation.  Int J Low Extrem Wounds.  2019 Apr.  Epub ahead of print.  PMID: 30929530.
4.    Lavery LA, Bhavan K, Wukich DK.  Biofilm and diabetic foot ulcer healing:  all hat and no cattle.  Annals of Translational Medicine 2019 Mar.  Epub ahead of print.
5.    La Fontaine J, Crisologo PA, Lavery L.  Current concepts in curative surgery for diabetic forefoot ulcers.  The Foot 2019 Jan 10 (39) 37-44.  Epub ahead of print.
6.    Olson E, Mahar KM, Morgan L, Fillmore C, Holland C, Lavery L.  Randomized Phase I Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Topical Daprodustat in Healthy Volunteers and Patients with Diabetic Foot Ulcers.  Clin Pharmacol Drug Dev. 2019 Feb 5. Epub ahead of print.  PMID:  30720931.
7.    Liu JW, Ahn J, Raspovic KM, Liu GT, Nakonezny PA, Lavery LA, Wukich DK.  Increased Rates of Readmission, Reoperation, and Mortality Following Open Reduction and Internal Fixation of Ankle Fractures are Associated with Diabetes Mellitus. J Foot Ankle Surg. 2019 Feb 11. Epub ahead of print.
8.    Ryan EC, Ahn J, Wukich DK, Kim PJ, La Fontaine J, Lavery LA.  Diagnostic Utility of Erythrocyte Sedimentation Rate and C-Reactive Protein in Osteomyelitis of the Foot in Persons without Diabetes.  J Foot Ankle Surg. 2019 Jan 23.  Epub ahead of print.
9.    Ahn J, Raspovic KM, Liu GT, Lavery LA, La Fontaine J, Nakonezny PA, Wukich DK.  Rental Function as a Predictor of Early Transmetatarsal Amputation Failure.  Foot Ankle Spec. 2018 Dec 12.  Epub ahead of print.  PMID:  30537872.
10.    Lavery LA, Crisologo PA.  Non-invasive vascular screening test to diagnose peripheral vascular disease.  Ann Transl Med. 2018 Dec; 6(Suppl 2).  PMID:  30740429.
11.    Yavuz M, Ersen A, Hartos J, LAVERY LA, Wukich D, Hirschman G, Armstrong D, Quiben M, Adams L.  Temperature as a Causative factor in Diabetic Foot Ulceration:  A Call to Revisit Ulcer Pathomechanics.  J Am Podiatr Med Assoc. 2018 Nov 14. (Epub ahead of print).  PMID:  30427732.
12.    Niederauer MQ, Michalek JE, Liu Q, Papas KK, LAVERY LA, Armstrong DG.  Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control:  a randomized, double-blind, multicenter study.  J Wound Care.  2018 Sep 1;27(Sup9): S30-S45. PMID: 30207844.
13.    LAVERY, LA, Fulmer J, Shebetka KAS, Regulski M, Vayer, D, Fried D, Kashefsky H, Owings TM, Nadarajah J, Phelan DHK.  Open-label Extension Phase of a Chronic Diabetic Foot Ulcer Multicenter, Controlled, Ramdomised Clinical Trial Using Cryopreserved Placental Membrance.  Wounds Epub 2018 June.  PMID:  30256747.
14.    Raspovic KM, Wukich DK, Naiman DQ, LAVERY LA, Kirsner RS, Kim PJ, Steinberg JS, Attinger CE, Danilkovitch A.  Effectiveness of viable cryopreserved placental membranes for management of diabetic foot ulcers in a real world setting.  Wound Repair Regen, 2018 Mar; 26(2): 213-220.  PMID:  29683538.
15.    Ahn J, Del Core MA, Wukich DK, Liu GT, Lalli T, VanPelt MD, La Fontaine J, Lavery LA, Raspovic KM.  Scoring mental health quality of life with the SF-36 in patients with and without diabetes foot complications.  Int J Low Extrem Wounds.  2018 Mar.  PMID:  29546783.
16.    LAVERY LA, Lavery DC, Hunt NA, La Fontaine J, Lavery RD.  Does the start of dialysis initiate a period of increased risk of ulceration or amputation?  J Am Podiatr Med Assoc.  2018 Jan; 108-(1):1-5.  PMID:  29547031.
17.    Van Asten SAV, Mithani M, Peters EIG, La Fontaine J, Kim PJ, Lavery LA.  Complications during the treatment of diabetic foot osteomyelitis.  Diabetes Res Clin Pract. 2018 Jan;135:58-64. PMID: 28951333. 
18.    Crisologo PA, Lavery LA.  Remote home monitoring to identify and prevent diabetic foot ulceration.  Ann Transi Med.  2017 Nov;5(21):430.  PMID:  29201882.
19.    Lavery LA, Ryan EC.  Does Continuous Diffusion of Oxygen Improve Diabetic Foot Ulcer Healing?  J Diabetes Sci Technol. 2017 Sep; 11(5):892-893.  PMID: 28728437.
20.    Sanniec K, Nguyen T, van Asten S, La Fontaine J, Lavery LA.  Split-Thickness Skin Grafts to the Foot and Ankle of Diabetic Patients.  J Am Podiatr Med Assoc.  2017 Sep; 107(5):365-368.  PMID:  29077498.

Research Interest: Dietetics Applied to Bariatric Ssurgery; Clinical Impact of Bariatric Surgery on Patient’s Body Composition (Fat Mass and Fat-Free Mass) and Resting Metabolic Rate; Pre- and Post-Operative Treatment of Micronutrient Deficiencies in Patients that Underwent Bariatric Surgery.

Dr. Gorelik has nearly 35 years of experience in clinical medicine and research. He has published more than 60 scientific publications. Currently, Dr. Gorelik serves as the Head of the Department of Internal Medicine "F" in the Assaf Harofeh Medical Center, Zerifin, Israel. He is also a Clinical Senior Lecturer in the Sackler Faculty of Medicine of the Tel Aviv University.

Research Interest: Diabetes, Orthostatic Hypotension, Magnesium Metabolism, Heart Failure and Hospital Internal Medicine.

Number of Publications: 57

Principal Investigator (PU) – UMR Inserm UMR-S1172

"Alzheimer & Tauopathies" Jean-Pierre Aubert Research Centre, 1 Place de Verdun, Lille, France, didier.vieau@inserm.fr, didier.vieau@univ-lille.fr

Professional experience  

1986-1990: PhD in Endocrinology. Pierre et Marie Curie University of Paris (Paris VI), France. Laboratory of Endocrinology, Cochin Hospital. Thesis supervisor (Pr X. Bertagna). Thesis title: “Proopiomelanocortin and neuroendocrine differentiation markers in human tumoral pathology”

1991-1995: Laboratory of Biochemical Endocrinology (Dr. NG Seidah), Clinical Research Institute of Montreal, Montreal, Canada.

1996-1999: European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology (Dr H Vaudry), University of Rouen, 76821 Mont-Saint-Aignan, France.

1999-2002: associate professor in the Laboratory of Endocrinology of Annelids (University of Lille 1, France, Pr M Salzet).

2002-2012: Professor of University (Animal Physiology) and head of the laboratory of maternal perinatal undernutrition (EA4489), University of Lille 1, France.

2012-2016: Dean of the department of Biology of the University Lille 1

September 2016-: Member of UMR Inserm UMR-S1172 "Alzheimer & Tauopathies" (Dr L Buée)

June 2019: Vice-President of the ‘Société des Sciences, des Arts et de l’Agriculture de Lille (SAAL)”

Research Interest: perinatal programming of metabolic disease, neuroendocrinology, Alzheimer disease, adaptation to stress.

Skype ID:  didier vieau (didiervieau@hotmail.com)

List of Publications:

Original papers

Ao 1. Vieau D, Massias JF, Girard F, Luton JP and Bertagna X. 1989. Corticotrophin like-intermediary lobe peptide as a marker of alternate proopiomelanocortin processing in ACTH producing non-pituitary tumors. Clin. Endocrinol.; 31 : 691-700.
Ao 2. Lalau JD, Vieau D, Tenenbaum F, Westeel PF, Mesmacque A, Lenne F and Quichaud J. 1990. A case of pseudo-Nelson’s syndrome : cure of ACTH hypersecretion by removal of a bronchial carcinoid tumor responsible for Cushing’s syndrome. J. Endocrinol. Invest.; 13 : 531-537.
Ao 3. de Keyzer Y, Lenne F, Massias JF, Vieau D, Luton JP, Kahn A and Bertagna X. 1990. Pituitary like proopiomelanocortin transcripts in human leydig cell tumors. J. Clin. Invest.; 86 : 871-877.
Ao 4. Massias JF, Hardouin S, Vieau D, Lenne F and Bertagna X. 1994. Phosphorylated forms of ACTH and CLIP in human tumors. Eur. J. Endocrinol.;  131 : 341-346.

Ao 5. Vieau D, Tougard C, Rosenbaum E, Lenne F and Bertagna X. 1991. The secretory granule peptide 7B2 is secreted in parallel with proopiomelanocortin and its end products by the mouse corticotrope cells At-T20. J. Neuroendocrinol.; 3 : 229-231.
Ao 6. Vieau D, Rojas-Miranda A, Verley JM, Lenne F and Bertagna X. 1991. The secretory granule peptides 7B2 and CCB are sensitive biochemicals markers of neuroendocrine bronchial tumors in man. Clin. Endocrinol.; 35 : 319-325.
Ao 7. Texier PL, de Keyzer Y, Lacave R, Vieau D, Lenne F, Rojas-Miranda A, Verley F, Luton JP, Kahn A and Bertagna X. 1991. Proopiomelanocortin gene expression in normal and tumoral human lung. J. Clin. Endocrinol. Metab.; 73 : 414-420.
Ao 8. Vieau D, Linard C, M’Bikay M, Lenne F, Chrétien M, Luton JP and Bertagna X. 1992. Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours. Clin. Endocrinol.; 36 : 597-603.
Ao 9. Lusson J, Vieau D, Hamelin J, Day R, Chrétien M and Seidah NG. 1993. cDNA structure of the mouse and rat subtilisin/kexin-like PC5 : a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proc. Natl. Acad. Sci. USA; 90 : 6691-6695.
Ao 10. Dong W, Marcinkiewicz M, Vieau D, Chrétien M, Seidah NG and Day R. 1995. Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J. Neuroscience; 15 : 1778-1796.
Ao 11. Vieau D, Seidah NG and Day R. 1995. Characterization of prodynorphin derived products in the mouse pancreatic tumoral cell line TC3 : a unique model for the study of prodynorphin processing. Endocrinology; 136 : 1187-1196.
Ao 12. Vieau D, Seidah NG, M’Bikay M, Chrétien M and Bertagna X. 1994. Expression of the prohormone convertase PC2 correlates with the presence of CLIP in human ACTH secreting tumors. J. Clin. Endocrinol. Metab.; 75 : 1503-1506. 
Ao 13. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Fournier A, Conlon JM and Vaudry H. 1996. Occurrence of two somatostatin variants in the frog brain : characterization of the cDNAs, distribution of the mRNAs and receptor-binding affinities of the peptides. Proc. Natl. Acad. Sci. USA; 93 : 12605-12610.
Ao 14. Vieau D, Gangnon F, Jégou S, Danger JM and Vaudry H. 1998. Characterization of the cDNA encoding the prohormone convertase PC2 and localization of the mRNA in the brain of the frog Rana ridibunda. Mol. Brain. Res.; 63 : 1-13.
Ao 15. Gangnon F, Danger JM, Jégou S, Vieau D, Seidah NG and Vaudry H. 1999. Molecular cloning, characterization of the cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1. J. Comp. Neurol.; 405 : 160-172.
Ao 16. Tostivint H, Vieau D, Chartrel N, Boutelet I, Galas L, Fournier A, Lihrmann I and Vaudry H. 2002. Expression and processing of the Pro2,Met13Somatostatin-14 precursor in the intermediate lobe of the frog pituitary. Endocrinology ; 143 : 3472-3481. 1er auteur ex æquo.

Ao 17. Sebaai N, Lesage J, Vieau D, Alaoui A, Dupouy JP, Deloof S. 2002. Altered control of the hypothalamo-pituitary-adrenal axis in adult male rats exposed perinatally to food deprivation and/or dehydration. Neuroendocrinology ; 76 : 243-253.
Ao 18. Gangnon F, Jegou S, Vallarino M, Vieau D and Vaudry H. 2003. Molecular characterization of the cDNA and localization of the mRNA encoding the Prohormone Convertase PC5-A in the European Green Frog. J. Comp. Neurol. ;456 : 60-72.

Ao 19. Matias I, Leonhardt M, Lesage J, De  Petrocellis L, Dupouy JP, Vieau D, Di Marzo V. 2003. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cell Mol Life Sci. ; 60 : 382-389.

Ao 20. Deloffre L, Salzet B, Vieau D, Andries JC, Salzet M. 2003. Antibacterial properties of hemerythrin of the sand worm Nereis diversicolor. Neuro Endocrinol Lett. ; 24 : 39-45.

Ao 21. Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D, Darnaudery M. 2004. Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J. Endocrinol. ; 181: 291-296. 

Ao 22. Deloffre L, Sautiere PE, Huybrechts R, Hens K, Vieau D, Salzet M. 2004. Angiotensin-converting enzyme inhibition studies by natural leech inhibitors by capillary electrophoresis and competition assay. Eur. J. Biochem. ; 271: 2101-2106.

Ao 23. Sebaai N, Lesage J, Breton C, Vieau D, Deloof S. 2004. Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period. Neuroendocrinology; 79 : 163-173.

Ao 24. Riviere G, Michaud A, Deloffre L, Vandenbulcke F, Levoye A, Breton C, Corvol P, Salzet M, Vieau D. 2004. Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): leech TtACE resembles the N-domain of mammalian ACE. Biochem J. ; 382 : 565-573.

Ao 25. Vergote D, Sautiere PE, Vandenbulcke F, Vieau D, Mitta G, Macagno ER, Salzet M. 2004. Up-regulation of neurohemerythrin expression in the central nervous system of the medicinal leech, Hirudo medicinalis, following septic injury. J. Biol. Chem. ; 279 : 43828-43837.

Ao 26. Levoye A, Mouillac B, Riviere G, Vieau D, Salzet M, Breton C. 2005. Cloning, expression and pharmacological characterization of a vasopressin-related receptor in an annelid, the leech Theromyzon tessulatum. J. Endocrinol. ; 184 : 277-289.

Ao 27. Laborie C, Dutriez-Casteloot I, Montel V, Dickes-Coopman A, Lesage J, Vieau D. 2005. Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress. Neurosci. Lett. ; 381:211-216.

Ao 28. Rivière G, Michaud A, Breton C, VanCamp G, Laborie C, Enache M, Lesage J, Deloof S, Corvol P, Vieau D. 2005. ACE2 and ACE display tissue-specific sensitivity to programmed hypertension by maternal undernutrition in the adult rat. Hypertension ; 46: 1169-1174.
Ao 29. Molendi-Coste O,  Grumolato L, Laborie C, Lesage J, Maubert E, Ghzili H, Vaudry H, Anouar Y, Breton C, Vieau D. 2006. Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Endocrinology ; 147 : 2050-2059.
Ao 30. Salomé N, Viltart O, Lesage J, Landgraf R, Vieau D, Laborie C. 2006. Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates. Psychoneuroendocrinology ; 31 : 724-735.
Ao 31. Vallarino M, Bruzzone F, Mathieu M, Chartrel N, Vieau D, Ciarlo M, Fournier A, Vaudry H. 2006. Ontogeny of the somatostatin variant [Pro(2), Met(13)]somatostatin-14 in the brain, pituitary, and sensory organs of the frog Rana esculenta. J. Comp. Neurol. ; 497: 717-733.
Ao 32 Brulle F, Mitta G, Cocquerelle C, Vieau D, Lemiere S, Lepretre A, Vandenbulcke F. 2006. Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure. Environ. Sci. Technol. 40: 2844-2850.
Ao 33. Van Waes V, Enache M, Dutriez I, Lesage J, Morley-Fletcher S, Vinner E, Lhermitte M, Vieau D, Maccari S, Darnaudery M. 2006. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Eur. J. Neurosci. 2:1193-200. 
Ao 34. Mairesse  J, Lesage J, Breton C, Bréant B, Hahn T, Darnaudéry M, Dickson S, Seckl J, Vanbesien-Mailliot C, Blondeau B, Vieau D, Maccari S, Viltart O. 2007. Maternal stress alters endocrine function of the feto-placental unit in rats. Am. J. Physiol. Endocrinol. Metab. 292 :E1526-E1533.
Ao 35. Rivière G, Michaud A, Corradi HR, Cogez V, Sturrock ED, Acharya KR, Bohin JP, Vieau D, Corvol P. 2007. Characterization of the first angiotensin-converting-like enzyme in bacteria : ancestor XcACE is already active. Gene 399: 81-90.
Ao 36. Dutriez-Casteloot, Breton C, Coupé B, Hawchar O, de Keyzer Y, Deloof S, Lesage J, Vieau D. 2008. Distribution and tissue-specific programming expression of glucocorticoid receptors and 11beta-HSDs by maternal perinatal undernutrition in the adult male rat: focus on HPA axis. Horm.Metab.Res. 40: 257-261.

Ao 37. Molendi-Coste O, Mairesse J, Aubert N, H. Ghzili H, Abbadie C, Vaudry H, Gonzalez B, Anouar Y, Vieau D, Breton C, Laborie C. 2008. Maternal perinatal undernutrition impairs chromaffin cells proliferation in the postnatal rat. Horm. Metab. Res. 40 : 386-390.
Ao 38. Grumolato L, Ghzili H, Montero-Hadjadje M, Lesage J, Galas L, Ait-Ali D, Guerineau N, Elkahloun A, Fournier A, Vieau D, Vaudry H, Anouar Y. 2008. Selenoprotein T is a PACAP- and cAMP responsive gene that localizes to the ER and regulates intracellular calcium. FASEB J. 22:1756-1768.
Ao 39. Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, Lesage J, Vieau D. 2008. Maternal Perinatal Undernutrition Impedes Postnatal Leptin Surge and Affects the Development of Arcuate Nucleus POMC Neurons in Neonatal Male Rat Pups. Endocrinology 149 :470-475.

Ao 40. Coupé B, Dutriez-Casteloot I, Breton C, Lefèvre F, Mairesse J, Dickes-Coopman A, Silhol M,  Tapia-Arancibia L, Lesage J, Vieau D. 2009. Maternal undernutrition modifies brain-derived neurotrophic factor expression and cell proliferation in the hippocampus and hypothalamus of the developing male rat. J. Neuroendocrinol. 21:40-48.
Ao 41. Molendi-Coste O, Laborie C, Scarpa MC, Montel V, Vieau D, Breton C. Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla. Neuroendocrinology 90:54-66.
Ao 42. Breton C, Risold PY, Lukaszewski MA, Enache M, Guillemot J, Rivière G, Delahaye F, Lesage J, Dutriez-Casteloot I, Laborie C, Vieau D. 2009. Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring. Am. J. Physiol. Endocrinol. Metab. 296: E462-E472.
Ao 43. Delahaye F, Lukaszewski MA, Cisse O, Dutriez-Casteloot I, Montel V, Dickes-Coopman A, Laborie C, Lesage J, Breton C, Vieau D. 2010. Maternal perinatal undernutrition programs a « brown-like » phenotype of gonadal white fat in male rat at weaning. Am J Physiol Regul Integr Comp Physiol. 299: R101-R110.

Ao 44. Mayeur S, Silhol M, Moitrot E, Barbaux S, Breton C, Gabory A, Vaiman D, Dutriez-Casteloot I, Fajardy I, Vambergue A, Tapia-Arancibia L, Bastide B, Storme L, Junien C, Vieau D, Lesage J. 2010. The placental BDNF/TRKB signaling system is modulated by fetal growth in rat and human. Placenta 31: 785-791.
Ao 45 Gallou-Kabani C., Gabory A., Tost J., Karimi M., Mayeur S., Lesage J., Boudadi E., Gross M.S., Taurelle J., Vige A., Breton C., Reusens B., Remacle C., Vieau D., Ekström T., Jais J.P., Junien C. 2010. Sex- and diet-specific dysregulation of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One 5: e14398.
Ao 46. Rivière G, Lienhard D, Andrieu T, Vieau D, Frey BM, Frey FJ. 2011. Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation. Epigenetics 6:478-89.
Ao 47. Tanguy Y., Falluel-Morel A., Arthaud S., Boukhzar L., Manecka D.L., Chagraoui A., Prevost G., Elias S., Dorval-Coiffec I., Lesage J., Vieau D., Lihrmann I., Jégou B., Anouar Y. 2011. The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Endocrinology 152: 4322-35.
Ao 48. Laborie C., Molendi-Coste O., Breton C., Montel V., Vandenbulcke F., Grumolato L., Anouar Y., Vieau D. 2011. Maternal perinatal undernutrition has long-term consequences both on morphology, function and gene expression of the adrenal medulla in the adult male rat. J. Neuroendocrinol. 23: 711-24.
Ao 49. Guillemot J.*, Lukaszewski M.A.*, Montel V., Delahaye F., Mayeur S., Laborie C., Dickes-Coopman A., Dutriez-Casteloot I., Lesage J., Breton C., Vieau D. 2011. Influence of prenatal undernutrition of clozapine and aripiprazole in the adult male rat: relevance to a neurodevelopmental origin of schizophrenia. Eur. J. Pharmacol. 667: 402-9. (*co-premier auteur).
Ao 50.  Lukaszewski M.A., Mayeur S., Fajardy I., Delahaye F., Dutriez-Casteloot I., Montel V., Dickes-Coopman A., Laborie C., Lesage J., Vieau D., Breton C. 2011. Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet. Am. J. Physiol. Endocrinol. Metab. 301: E548-59.
Ao 51. Ivars J., Butruille L., Knauf C., Bouckenooghe T., Mayeur S., Vieau D., Valet P., Deruelle P., Lesage J. 2012. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat. Peptides 35: 136-8.
Ao 52. Gabory A., Ferry L. Fajardy I., Jouneau L., Gothié J.D., Vigé A., Fleur C., Mayeur S., Gallou-Kabani C., Gross M.S., Attig l., Vambergue A., Lesage J., Reusens B., Vieau D., Remacle C., Jais J.P., Junien C. 2012. Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. PLoS One 7: e47986.
Ao 53. Mayeur S., Lancel S., Theys N., Lukaszewski M.A., Duban-Deewer S., Bastide B., Hachani J., Cecchelli R., Breton C., Gabory A., Storme L., Reusens B., Junien C., Vieau D., Lesage J. 2013. Maternal caloric restriction induces placental mitochondrial biogenesis, optimizes bioenergetic efficiency but alterates ATP production: putative involvement of mitochondria in feto-placental growth defects. Am. J. Physiol. Endocrinol. Metab. 304: E14-22.
    Ao 54. Lukaszewski M.A., Butruille L., Moitrot E., Montel V., Dickes-Coopman A., Lesage J., Laborie C., Vieau D., Breton C. 2013. The hypothalamic POMC gene expression exhibits long-term programming in prenatally undernourished male rat offspring under high-fat diet. Peptides 43: 146-54.
    Ao 55. Cisse O., Fajardy I., Dickes-Coopman A., Moitrot E., Montel V., Deloof S., Rousseaux J., Vieau D., Laborie C. 2013. Mild gestational hyperglycemia in rat induces fetal overgrowth and modulates placental growth factors and nutrient transporters expression. PLoS One 8: e64251.
Ao 56. Mayeur S., Cisse O., Gabory A., Barbaux S., Vaiman D., Vambergue A., Fajardy I., Deloof S., Junien C., Laborie C., Vieau D., Lesage J. 2013. Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rat and human. J. Dev. Orig. Health Dis. 4: 134-138.
Ao 57. Wattez JS, Ravallec R, Cudennec B, Knauf C, Dhulster P, Valet P, Breton C, Vieau D, Lesage J.2013. Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents. Peptides. Oct;48:134-6.

Ao 58. Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C.2014. Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes. .Antioxid Redox Signal. 20 : 557-573.

Ao 59. Wattez JS, Delahaye F, Barella LF, Dickes-Coopman A, Montel V, Breton C, Mathias P, Foligné B, Lesage J, Vieau D. 2014. Short- and long-term effects of maternal perinatal undernutrition are lowered by cross-fostering during lactation in the male rat. J. Dev. Orig. Health Dis. Doi: 10.1017/S2040174413000548: 1-12.

Ao 60. Elmhiri G, Barella LF, Vieau D, Camous S, Mathias PC, Abdennebi-Najar L. 2014. Acute exposure to a precursor of Advanced Glycation End Products induces a dual effect on the rat pancreatic islet function. Int Journal Endocrinol 2014:378284.

Ao 61. Wattez JS, Delmont A, Bouvet M, Beseme O, Goers S, Delahaye F, Laborie C, Lesage J, Foligné B, Breton C, Metges C, Vieau D, Pinet . 2015. Maternal perinatal undernutrition modifies lactose and serotransferrin in milk: relevance to the programming of metabolic diseases? Am J Physiol Endocrinol Metab, 308 : E393-E401. Dernier auteur ex aequo.

Ao 62. Malta A, de Moura EG, Ribeiro TA, Tófolo LP, Abdennebi-Najar L, Vieau D, Barella LF, de Freitas Mathias PC, Lisboa PC, de Oliveira JC. 2016. Protein-energy malnutrition at mid-adulthood does not imprint long-term metabolic consequences in male rats. Eur J Nutr. 55(4):1423-33.

Ao 63. Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. 2016. Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition. Diabetes. 65(3):554-60.

Ao 64. Lecoutre S, Deracinois B, Laborie C, Eberlé D, Guinez C, Panchenko PE, Lesage J, Vieau D, Junien C, Gabory A, Breton C. 2016. Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue. J Endocrinol 230 : 39-53.

Ao 65. Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C. 2017. Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring. J Dev Orig Health Dis. Feb;8(1):3-7.

Ao 66. Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy E, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D. 2017. Tau deletion promotes brain insulin resistance. J Exp Med.214 (8): 2257-2269.
Ao 67. Lecoutre S, Oger F, Butruille L, Marousez L, Dickes-Coopman A, Pourpe C, Laborie C, Eberlé D, Guinez C, Lesage J, Vieau D, Junien C, Gabory A, Eeckhoute J, Breton C. 2017. Maternal obesity affects leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner. Molecular Metab.6 (8): 922-930.
Ao 68. Lecoutre S, Pourpe C, Butruille L, Marousez L, Laborie C, Guinez C, Lesage J, Vieau D, Eeckhoute J, Gabory A, Oger F, Eberle D, Breton C. 2018. Reduced PPARgamma 2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications. Faseb J. Jan 2. pii: fj.201700997R. doi: 10.1096/fj.201700997R.
Ao 69. Cissé O, Fajardy I, Delahaye F, Dickes A, Montel V, Moitrot E, Breton C, Vieau D, Laborie C. 2018. Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific. Eur J Nutr. doi: 10.1007/s00394-018-1794-y.

Ao 70. Leboucher A, Ahmed T, Caron E, Tailleux A, Raison S, Joly-Amado A, Marciniak E, Carvalho K, Hamdane M, Bantubungi K, Lancel S, Eddarkaoui S, Caillierez R, Vallez E, Staels B, Vieau D, Balschun D, Buee L, Blum D. 2019. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiol Dis. 125:14-22.

Reviews and chapters of books

R1. Vieau D, Gicquel C et Proeschel MF. 1991. La proopiomélanocortine et ses fragments : applications à l’investigation clinique. Médecine Sciences; 7: 918-926.
R2. Day R, Vieau D and Seidah NG. 1994. Approaches in the study of the posttranslational processing of opioid peptide precursors : focus on prodynorphin. Regul. Peptides; 54 : 77-78.
R3. Raffin-Sanson ML, Vieau D, de Keyzer Y et Bertagna X. 1995. Hormones corticolipotropes et endorphines. Encyclopédie Médico-chirurgicale.
R 4. de Keyzer Y, Vieau D, Picon A and Bertagna X. 1996. Molecular aspects of the ectopic ACTH syndrome. Endocrine-Related Cancer; 3 : 99-112.
R5. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Fournier A, Conlon JM, Vaudry H, Dournaud P, Gardette R, Viollet C et Epelbaum J. 1996. Un deuxième gène codant pour la somatostatine est exprimé dans le cerveau. Médecine Sciences; 12 : 1131-1133.
R6. Chartrel N, Braun B, Collin F, Pierreuse B, Coulouarn Y, Tostivint H, Jeandel L, Trabucchi M, Vieau D, Lihrmann I, Tonon MC, Anouar Y, Conlon JM et Vaudry H. 1998. Stratégie d’identification de nouveaux neuropeptides. CR. Soc. Biol.; 192 : 619-638.
R7. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Boutelet I, Fournier A, Conlon JM, Vaudry H. 1998. A second somatostatin gene is expressed in the brain of the frog Rana ridibunda . Trends in Comparative Endocrinology and Neurobiology. Annals of the New York Academy of sciences 839: 496-497.

R8. Salzet M, Vieau D and Stefano G. 1999. Serpins : a survival strategy in immunity. Immunol. Today ; 20 : 541-544. Ce journal est devenu Trends in Immunology.
R9. Salzet M, Vieau D and Day R. 2000. Crosstalk between nervous and immune systems through the animal kingdom : focus on opioids. Trends in Neuroscience; 23 : 550-555.
R10. Tasiemski A, Lefebvre C, Vieau D and Salzet M. 2000. Immune response stimulation pathway : implications of opioid peptides. Crit. Trends in Immunol.; 2 : 209-216.
R11. Salzet M, Deloffre L, Breton C, Vieau D and Schoofs L. 2001. The angiotensin system elements in invertebrates. Brain Res. Rev. ; 36 : 35-45.
R12. Gangnon F, Danger JM, Jégou S, Vieau D, Vaudry H. 2002. Characterization of the three prohormone-convertases potentially involved in the processing of neuropeptide precursors in the european green frog. Proceedings of the 21st Conference of European Comparative Endocrinologists : 507-512.
R13. Gangnon F, Vieau D, Jégou S and Vaudry H. 2003. Cloning of the cDNA and comparative distribution of frog PC1 and PC2, the major proteolytic enzymes involved in the processing of neuropeptides. Recent Progress in Comparative Endocrinology and Neurobiology.
R14. Chartrel N, Braun B, Desrues L, Yon L, Vieau D, Kodjo M, Cellier E, Kikuyama S, Delarue C, Tonon MC and Vaudry H. 2003. Identification of novel neuropeptides from the amphibian brain. Recent Progress in Comparative Endocrinology and Neurobiology.
R15. Salzet M., Vieau, D., Breton, C. 2004. Cell signalling in prokaryotes and lower metazoa. (Ed. Fairweather I), Kluwer Publisher. Evidence for an annelid neuroendocrine system (Chapter 9).
R16. Lesage J, Sebaai N, Léonhardt M, Dutriez-Casteloot I, Breton C, Deloof S, Vieau D. 2006. Maternal undernutrition and HPA axis in the offspring. Stress ; 9 : 183-198.
R17. Vieau D, Sebaai N, Léonhardt M, Dutriez-Casteloot I, Molendi-Coste O, Laborie C, Breton C, Deloof S, Lesage J. 2007. HPA axis programming by maternal undernutrition in the male rat offspring. Psychoneuroendocrinology 32 (supl 1): S16-S20.
R18. Vieau D, Mayeur S, Lukaszewski MA, Delahaye F, Dutriez-Casteloot I, Laborie C, Deloof, S, Lesage J, Breton C. 2009. Perinatal undernutrition and brain derived nerve factor. The International Handbook of behavior, diet and nutrition.
R19. Vieau D. 2009. La dénutrition maternelle programme les systèmes neuroendocriniens impliqués dans la réponse au stress chez le rat mâle adulte : rôle dans la genèse du syndrome métabolique ? Médecine et nutrition 45 (1) : 1-6.
R20. Vieau D. 2009. Maternal undernutrition programs hypothalamo-pituitary-adrenal (HPA) axis activity. Endocrinologia & Diabetes Clinica e experimental 9 (4): 1068-1070.
R21. Mayeur S., Lukaszewski M.A., Breton C., Storme L., Vieau D., Lesage J. 2011. Do neurotrophins regulate the feto-placental development? Med. Hypotheses 76: 726-8.
R22. Vieau D. 2011. Perinatal nutritional programming of health and metabolic adult disease. World J Diabetes 2: 133-6.
R23. Mayeur S., Lukaszewski M.A., Breton C., Storme L., Junien C., Vieau D., Lesage J.  2011. BDNF in feto-placental development. Med. Sci. (Paris) 27: 251-2.
R 24. Guillemot J., Laborie C., Dutriez-Casteloot I., Maron M., Deloof S., Lesage J., Breton C., Vieau  D. 2011. Could maternal perinatal atypical antipsychotic treatments program later metabolic diseases in the offspring? Eur. J. Pharmacol. 667: 13-6.
R25. Lukaszewski M.A., Delahaye F., Vieau D., Breton C. 2012. Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition? Adipocyte 1:64-7.
R26. Wattez J.S., Delahaye F., Lukaszewski M.A., Eberlé D., Vieau D., Breton C. 2013. Maternal nutrition programs hypothalamic POMC neurons in the offspring. Horm. Metab. Res. 45: 980-990.
    R27. Vieau D., Breton C., Dutriez-Casteloot I., Montel V., Dickes-Coopman A., Deloof S., Lesage J., Laborie C. 2011. Maternal perinatal undernutrition programs stress neuroendocrine systems in the male rat. Lee JE. Undernutrition: Effects, Causes and Management. Hauppage, New York: Nova Science Publishers, 1-23.
    R28. Vieau D., Mayeur S., Dutriez-Casteloot I., Lukaszewski M.A., Delahaye F.,  Laborie C., Deloof S., Lesage J., Breton C. 2013. Perinatal undernutrition and brain derived factor. International Handbook of Behavior, Diet and Nutrition (Preedy V.R., eds.), Springer.
R29. Lukaszewski MA, Eberlé D, Vieau D, Breton C. 2013. Nutritional manipulations in the perinatal period program adipose tissue in offspring. Am J Physiol Endocrinol Metab. 305 : E1195-E1207.

R30. Vieau D, Laborie C, Eberlé D, Lesage J, Breton C. 2016. Nutrition périnatale et programmation : le tissu adipeux est en dans le collimateur. Médecine Sciences 32 : 81-84.

R31. Vercruysse P, Vieau D, Blum D, Petersen A, Dupuis L. 2018. Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism. Front. Mol. Neurosci. 11:2. doi: 10.3389/fnmol.2018.00002.

R32. Gratuze M, Joly-Amado A, Vieau D, Buée L, Blum D. 2018. Mutual relationship between Tau and central insulin signalling: consequences for Alzheimer disease and Tauopathies. Neuroendocrinology 107(2):181-195.

R33. Cellai L, Carvalho K, Faivre E, Deleau A, Vieau D, Buée L, Blum D, Mériaux C, Gomez Murcia V. 2018. The adenosinergic signaling : a complex but promising therapeutic target for Alzheimer’s disease. Front. Neurosci. 12:520.

R34. Joly-Amado A, Gratuze M, Benderradji H, Vieau D, Buée L, Blum D. 2018. Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies. Med Sci (Paris). 2018 Nov;34(11):929-935.

Research Interest: Epidemiology of Diabetes; Mechanism of Insulin Action; Insulin Resistance; Obesity and Insulin Resistance; Cardiovascular Risk Diabetes and Obesity; Bone Metabolism and Diabetes and Obesity; Gene Adiposities Tissue in Diabetes and Obesity. 

Research Interest:

1. Obesity and metabolic diseases
2. Effect of sport in obesity and cardio-metabolic disturbances
3. Role of environmental pollutant in cardio-metabolic diseases

List of Publications:

1.    Della Guardia L, Shin AC. The role of adipose tissue dysfunction in PM2.5-induced vascular pathology. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H971-H972. doi: 10.1152/ajpheart.00156.2022
2.    De Nardi M, Bisio A, Della Guardia L, Facheris C, Faelli E, La Torre A, Luzi L, Ruggeri P, Codella R. Partial-Body Cryostimulation Increases Resting Energy Expenditure in Lean and Obese Women. Int J Environ Res Public Health. 2021 Apr 14;18(8):4127. doi: 10.3390/ijerph18084127.
3.    Della Guardia L, Shin AC. White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure. J Mol Med (Berl). 2022 May;100(5):665-676. doi: 10.1007/s00109-022-02183-6. Epub 2022 Mar 14
4.    Della Guardia L, Codella R. Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions. Cytokine Growth Factor Rev. 2021 Dec;62:83-93. doi: 10.1016/j.cytogfr.2021.09.003.
5.    Codella R, Della Guardia L, Terruzzi I, Solini A, Folli F, Varoni EM, Carrassi A, Luzi L. Physical activity as a proxy to ameliorate inflammation in patients with type 2 diabetes and periodontal disease at high cardiovascular risk. Nutr Metab Cardiovasc Dis. 2021 Jul 22;31(8):2199-2209. doi: 10.1016/j.numecd.2021.04.022.
6.    Della Guardia L, Codella R. Airways to heaven: Caution needed when exercising during COVID-19. Med Hypotheses. 2021 Mar;148:110522. doi: 10.1016/j.mehy.2021.110522.
7.    Moreno C, Della Guardia L, Shnyder V et al. iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signal. Mol Neurodegener. 2018 Jun 26;13(1):33. doi: 10.1186/s13024-018-0265-5.
8.    Maurizi G, Babini L, Della Gaurdia L. Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology. Journal of Cellular Physiology.
9.    Della Guardia L, Thomas MA, Cena H. Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load. Nutrients 2018, 10, 618; doi:10.3390/nu10050618
10.    Maurizi G, Petäistö T, Maurizi A, Della Guardia L. Key-genes regulating the liposecretion process of mature adipocytes. J Cell Physiol. 2018 May;233(5):3784-3793.
11.    Manuelli M, Della Guardia L, Cena H. Enriching Diet with n-3 PUFAs to Help Prevent Cardiovascular Diseases in Healthy Adults: Results from Clinical Trials. Int J Mol Sci. 2017 Jul 18;18(7)
12.    Maurizi G, Della Guardia L, Maurizi A, Poloni A. Adipocytes properties and crosstalk with immune system in obesity-related inflammation. J Cell Physiol. 2018;233:88–97.
13.    Della Guardia L, Roggi C, Cena H. Diet-induced acidosis and alkali supplementation. Int J Food Sci Nutr. 2016 Jun 24:1-8.
14.    Della Guardia L, Cavallaro M, Cena H. The risks of self-made diets: the case of an amateur bodybuilder. J Int Soc Sports Nutr. 2015 Apr 1;12:16.
15.    Della Guardia L. Guarene M. Calcaterra V Vandoni M Cena H. Effects of a multidisciplinary intervention on childhood obesity". 2nd N&G conference Barcelona. 30 Jen-2 Feb 2014.
16.    Guarene M. Calcaterra V, De Giuseppe R, Della Guardia L, et al. Lifestyle, nutritional Knowledge and fears of a group of adolescents suffering from type 1 diabetes. Clin Nutr 2014 Sep (Supp); 33:S174

Research Interest: Epidemiology, pathogenesis, diagnosis and treatment of fatty liver (metabolic and viral); genetic determinants of fatty liver; metabolic syndrome; insulin resistance; association between fatty liver, metabolic syndrome, diabetes and cardiovascular diseases;  liver ultrasonography.

Research Interest: Rehabilitation, Working with Older People, Diabetes, Stroke Care, Research 

Research Interest: My Research Interests Span Many Areas Including Bioinformatics and Metabolomics. As a Phd Student at Center of Magnetic Resonance of University of Florence (Italy), My Research Focused on the Metabolomic Analysis of Biofluid (E.G., Urine, Serum, Saliva) and Tissue (E.G., Intact Human Liver) Samples. I Used Nuclear Magnetic Resonance (NMR) Spectroscopy and Advanced Statistical Analysis Techniques to Identify and Predict Metabolomic Fingerprints. In Particular, I Used NMR-Based Metabolomic Analysis to Identify a Fingerprint of Poor-Survival in the Serum of Patient with Metastatic Colorectal Cancer.
Now as Postdoc at Dana-Farber Cancer Institute, My Current Research Focuses on Identifying Metabolic Fingerprint Predictors of Prostate Cancer Development and Progression to Improve our Understanding of The Mechanisms Linking Metabolism with the Biology of Prostate Cancer. Moreover, I Will Contribute on Developing of New Standard Operation Procedures for Metabolomic Analysis in Formalin Fixed Paraffin Embedded Tissues.