Research Interest: Immunology such as Autoimmune Diabetes (Type 1).

Research Interest: Metabolic and Bariatric Surgery, Gastrointestinal Surgery, Thyroid Surgery, Hepatobiliary Surgery, Hernia Surgery, Anorectal Surgery, General Surgery.

Research Interest: Application of Multiple Linear and Logistic Regression Models, Applied Longitudinal Data Analysis, Generalized Linear and Non-Linear Mixed Models, and Survival Analysis; Epidemiology of Chronic Diseases Including Alcohol use Disorders and Drug Abuse, Alzheimer’s Disease, Cancer, Obesity and Diabetes, Heart Disease and Stroke; Genetic Epidemiology of Complex Diseases Including Alcohol Dependence And Comorbidity, Obesity, Diabetes and Related Conditions, Depression and Schizophrenia.

Research Interest: Epidemiology of Diabetes; Mechanism of Insulin Action; Insulin Resistance; Obesity and Insulin Resistance; Cardiovascular Risk Diabetes and Obesity; Bone Metabolism and Diabetes and Obesity; Gene Adiposities Tissue in Diabetes and Obesity. 

Research Interest:

1. Obesity and metabolic diseases
2. Effect of sport in obesity and cardio-metabolic disturbances
3. Role of environmental pollutant in cardio-metabolic diseases

List of Publications:

1.    Della Guardia L, Shin AC. The role of adipose tissue dysfunction in PM2.5-induced vascular pathology. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H971-H972. doi: 10.1152/ajpheart.00156.2022
2.    De Nardi M, Bisio A, Della Guardia L, Facheris C, Faelli E, La Torre A, Luzi L, Ruggeri P, Codella R. Partial-Body Cryostimulation Increases Resting Energy Expenditure in Lean and Obese Women. Int J Environ Res Public Health. 2021 Apr 14;18(8):4127. doi: 10.3390/ijerph18084127.
3.    Della Guardia L, Shin AC. White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure. J Mol Med (Berl). 2022 May;100(5):665-676. doi: 10.1007/s00109-022-02183-6. Epub 2022 Mar 14
4.    Della Guardia L, Codella R. Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions. Cytokine Growth Factor Rev. 2021 Dec;62:83-93. doi: 10.1016/j.cytogfr.2021.09.003.
5.    Codella R, Della Guardia L, Terruzzi I, Solini A, Folli F, Varoni EM, Carrassi A, Luzi L. Physical activity as a proxy to ameliorate inflammation in patients with type 2 diabetes and periodontal disease at high cardiovascular risk. Nutr Metab Cardiovasc Dis. 2021 Jul 22;31(8):2199-2209. doi: 10.1016/j.numecd.2021.04.022.
6.    Della Guardia L, Codella R. Airways to heaven: Caution needed when exercising during COVID-19. Med Hypotheses. 2021 Mar;148:110522. doi: 10.1016/j.mehy.2021.110522.
7.    Moreno C, Della Guardia L, Shnyder V et al. iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signal. Mol Neurodegener. 2018 Jun 26;13(1):33. doi: 10.1186/s13024-018-0265-5.
8.    Maurizi G, Babini L, Della Gaurdia L. Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology. Journal of Cellular Physiology.
9.    Della Guardia L, Thomas MA, Cena H. Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load. Nutrients 2018, 10, 618; doi:10.3390/nu10050618
10.    Maurizi G, Petäistö T, Maurizi A, Della Guardia L. Key-genes regulating the liposecretion process of mature adipocytes. J Cell Physiol. 2018 May;233(5):3784-3793.
11.    Manuelli M, Della Guardia L, Cena H. Enriching Diet with n-3 PUFAs to Help Prevent Cardiovascular Diseases in Healthy Adults: Results from Clinical Trials. Int J Mol Sci. 2017 Jul 18;18(7)
12.    Maurizi G, Della Guardia L, Maurizi A, Poloni A. Adipocytes properties and crosstalk with immune system in obesity-related inflammation. J Cell Physiol. 2018;233:88–97.
13.    Della Guardia L, Roggi C, Cena H. Diet-induced acidosis and alkali supplementation. Int J Food Sci Nutr. 2016 Jun 24:1-8.
14.    Della Guardia L, Cavallaro M, Cena H. The risks of self-made diets: the case of an amateur bodybuilder. J Int Soc Sports Nutr. 2015 Apr 1;12:16.
15.    Della Guardia L. Guarene M. Calcaterra V Vandoni M Cena H. Effects of a multidisciplinary intervention on childhood obesity". 2nd N&G conference Barcelona. 30 Jen-2 Feb 2014.
16.    Guarene M. Calcaterra V, De Giuseppe R, Della Guardia L, et al. Lifestyle, nutritional Knowledge and fears of a group of adolescents suffering from type 1 diabetes. Clin Nutr 2014 Sep (Supp); 33:S174

Dr. Gorelik has nearly 35 years of experience in clinical medicine and research. He has published more than 60 scientific publications. Currently, Dr. Gorelik serves as the Head of the Department of Internal Medicine "F" in the Assaf Harofeh Medical Center, Zerifin, Israel. He is also a Clinical Senior Lecturer in the Sackler Faculty of Medicine of the Tel Aviv University.

Research Interest: Diabetes, Orthostatic Hypotension, Magnesium Metabolism, Heart Failure and Hospital Internal Medicine.

Number of Publications: 57

Research Interest: My Research has Focused on Understanding the BBB, Changes that Occur in the Blood-Tumor-Barrier (BTB), and Drug Uptake Therein. To this End, I Have Worked and Gained Significant Amount of Knowledge on Factors Influencing Anticancer Delivery and Activity in Brain aBrain Metastases Developed from Breast Cancer in Mouse Models. These Include: (1) How BBB is Altered in Mouse Models of Brain Metastases of Breast Cancer. (2) Pharmacokinetic-Pharmacodynamic Relationship of Anticancer Drugs in Brain Metastases. (3) in Vitro- In Vivo Correlations (IVIVC) to Predict Optimum Therapeutic Concentrations for Treatment of Brain Metastases. (4) Improving Targeted Anticancer Drug Delivery to Brain Tumors by Inhibiting Efflux Transporters and Piggy Backing Drugs to Substrates of Influx Transporters at the BBB.

Research Interest: Medicinal Herbs, Behavioral Pharmacology, Neurodegeneration, Neurotransmitters, Neuroscience, Diabetes, Inflammation

Research Interest: Obesity, Mind and Inhibitory Control, Metabolic Syndrome, Rationale, Cardiovascular Disease 

Research Interest: My Research Interests Span Many Areas Including Bioinformatics and Metabolomics. As a Phd Student at Center of Magnetic Resonance of University of Florence (Italy), My Research Focused on the Metabolomic Analysis of Biofluid (E.G., Urine, Serum, Saliva) and Tissue (E.G., Intact Human Liver) Samples. I Used Nuclear Magnetic Resonance (NMR) Spectroscopy and Advanced Statistical Analysis Techniques to Identify and Predict Metabolomic Fingerprints. In Particular, I Used NMR-Based Metabolomic Analysis to Identify a Fingerprint of Poor-Survival in the Serum of Patient with Metastatic Colorectal Cancer.
Now as Postdoc at Dana-Farber Cancer Institute, My Current Research Focuses on Identifying Metabolic Fingerprint Predictors of Prostate Cancer Development and Progression to Improve our Understanding of The Mechanisms Linking Metabolism with the Biology of Prostate Cancer. Moreover, I Will Contribute on Developing of New Standard Operation Procedures for Metabolomic Analysis in Formalin Fixed Paraffin Embedded Tissues. 

Research Interest: Deep Specialization in Research Involve; Obesity and Associated Disorder, Its Mechanism and Treatment. Metabolic Syndrome-Food Additives and Its Effect on the Bodyorgans. Also the Biochemical, Oxidative Stress and Advanced Biomarkers in Health and Diseases. Recently Involved in Nanomedical Materials as Antioxidant for Health Maintainance.

Research Interest: Area of Gastrointestinal Cancer and Inflammatory Bowel Disease. 

Research Interest: Evaluation of biological activity of plant foods: anti-inflammatory, anti-glycation, anti-oxidant activities Influences of heat treatment on biological activity of foods.

List of Publications:

1.    Ho, Su-Chen, Chang, Yi-Huang, “Comparison of inhibitory capacities of 6-, 8- and 10-gingerols/shogaols on the canonical NLRP3 inflammasome-mediated IL-1β secretion” Molecules, Vol. 23, 2018, 02, p. 466.
2.    Ho, Su-Chen, Su, Min-Sheng, Lin, Chih- Cheng, Chiu, Chui-Feng, “Comparison of anti-glycation capacity of two new purple-colored-leaf tea cultivars with an ordinary green-colored-leaf tea cultivar in Taiwan,” Global Journal of Obesity, Diabetes and Metabolic Syndrome, Vol. 4, No. 1, 2017, 02, pp. 009-015.
3.    Yang, Tzu-Ting, Ho, Su-Chen, Chuang, Lu-Te, Chuang, Hsiao-Chi, Li, Ya-Ting, Wu, Jyun-Jie, “Characterization of particulate-phase polycyclic aromatic hydrocarbons emitted from incense burning and their bioreactivity in RAW264.7 macrophage,” Environmental Pollution, Vol. 220, 2017, 01, pp. 1190-1198.
4.    Ho, Su-Chen, Su, Min-Sheng, “Optimized heat treatment enhances the anti-inflammatory capacity of ginger “ International Journal of Food Properties, Vol. 19, 2016, pp. 1884-1898.
5.    Ho, Su-Chen, Su, Min-Sheng, “Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds,” Molecules, Vol. 19, No. 11, 2014, pp. 17697-17714.
6.    Ho, Su-Chen, Kuo, Chun-Ting, “Hesperidin, Nobiletin, and Tangeretin Are Collectively Responsible for the Anti-neuroinflammatory Capacity of Tangerine Peel (Citri reticulatae pericarpium)” Food and Chemical Toxicology, Vol. 71, 2014, pp. 176-182.
7.    Ho, Su-Chen, Chang, Pei-Wen, Tong, Hui-Ting, Yu, Pin-Yuan, “Inhibition of Fluorescent Advanced Glycation End-products and N-carboxymethyllysine Formation by Several Floral Herbal Infusions,” International Journal of Food Properties, Vol. 17, 2014, pp. 617-628.
8.    Ho, Su-Chen, Su, Min-Sheng, Lin, Chih-Cheng, “Comparison of Peroxynitrite-Scavenging Capacities of Several Citrus Fruit Peels,” International Journal of Food Properties, Vol. 17, 2014, pp. 111-124.
9.    Ho, Su-Chen, Chang, Ku-Shang, Lin, Chih-Cheng, “Anti-neuroinflammatory Capacity of Fresh Ginger Is Attributed Mainly to 10-Gingerol,” Food Chemistry, Vol. 141, No. 3, 2013, 12, pp. 3183-3191.
10.    Ho, Su-Chen, Chang, Ku-Shang, Chang, Pei-Wen, “Inhibition of Neuroinflammation by Cinnamon and its Main Components,” Food Chemistry, Vol. 138, No. 4, 2013, pp. 2275-2282.
11.    Ho, Su-Chen, Chang, Pei-Wen, “Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts,” American Journal of Plant Sciences, Vol. 3, No. 7, 2012, pp. 995-1002.
12.    Ho, Su-Chen, Wu, Szu-Pei, Lin, Shyh-Mirn, Tang, Ya-Li, “Comparison of Anti-glycation Capacities of Several Herbal Infusions with that of Green Tea,” Food Chemistry, Vol. 122, 2010, pp. 768-744.
13.    Lin, Shih-Min, Wang, Shih-Wei, Ho, Su-Chen, Tang, Ya-Li, “Protective Effect of Green Tea (-)-Epigallocatechin-3-gallate (EGCG) Against the Monoamine Oxidase B Enzyme Activity Increase in Adult Rat Brains,” Nutrition, Vol. 26, 2010, pp. 1195-1200.
14.    Huang, Yung-Sheng, Ho, Su-Chen, “Polymethoxy Flavones Are Responsible for the Anti-inflammatory Activity of Citrus Fruit Peel,”Food Chemistry, Vol. 119, 2010, pp. 868-873.
15.    Ho, Su-Chen, Tang, Ya-Li, Lin, Shih-Min, Liew, Yih-Fong, “Evaluation of Peroxynitrite-Scavenging Capacities of Several Commonly Used Fresh Spices,” Food Chemistry, Vol. 119, 2010, pp. 1102-1107.
16.    Ho, Su-Chen, Lin, Chih-Cheng, “Investigation of Heat Treating Conditions for Enhancing the Anti-inflammatory Activity of Citrus Fruit (Citrus reticulata) Peels,”Journal of Agricultural and Food Chemistry, Vol. 56, 2008, pp. 7976-7982.
17.    Lin, Chih-Cheng, Hung, Pi-Fong, Ho, Su-Chen, “Heat Treatment Enhances the NO-suppressing and Peroxynitrite-intercepting Activities of Kumquat’s (Fortunella margarita Swingle) Peel,”Food Chemistry, Vol. 109, 2008, pp. 95-103.
18.    Ho, Su-Chen, Tsai, Tzung-Hsun, Tsai, Po-Jung, Lin, Chih-Cheng, “Protective Capacities of Certain Spices Against Peroxynitrite-mediated Biomolecular Damage,”Food and Chemical Toxicology, Vol. 46, 2008, pp. 920-928.
19.    Ho, Su-Chen, Hwang, Lucy Sun, Shen, Yi-Jane, Lin, Chih-Cheng, “Suppressive Effect of a Proanthocyanidin-rich Extract from Longan (Dimocarpus longan Lour.) Flowers on Nitric Oxide Production in LPS-Stimulated Macrophage Cells,”Journal of Agricultural and Food Chemistry, Vol. 55, No. 26, 2007, pp. 10664-10670.
20.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Ho, Su-Chen, “In vitro Inhibitory Effects of Rosemary Extracts on Growth and Glucosyltransferase Activity of Streptococcus sobrinus,” Food Chemistry, Vol. 105, 2007, pp. 311-316.
21.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Evaluation of NO-suppressing Activity of Several Mediterranean Culinary Spices,” Food and Chemical Toxicology, Vol. 45, 2007, pp. 440-447.
22.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Comparison of NO-scavenging and NO-suppressing Activities of Different Herbal Teas with those of Green Tea,” Food Chemistry, Vol. 103, 2007, pp. 181-187.
23.    Lin, Chih-Cheng, Lu, Min-Jer, Chen, Shen-Jen, Ho, Su-Chen, “Heavy Fermentation Impacts NO-Suppressing Activity of Tea in LPS-activated RAW 264.7 Macrophages,” Food Chemistry, Vol. 98, 2006, pp. 483-489.
24.    Tsai, Tzung-Hsun, Tsai, Po-Jung, Ho, Su-Chen, “Antioxidant and Antiinflammatory Activities of Several Commonly Used Spices,” Journal of Food Science, Vol. 70, No. 1, 2005, pp. pp. C93-C97.
25.    Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Huang IT, Ho, Su-Chen, Chu CH “Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: Negative association with gestational diabetes mellitus” Nutrition, Vol. 21, No. 11-12, 2005, pp.1095-9 •
26.    Tsai, Po-Jung, Ho, Su-Chen, Tsai LP, Lee YH, Hsu SP, Yang SP, Chu CH, Yu, Chun-Hsien, “Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population” Metabolism, Vol. 53, No. 9, 2004, pp.1136-9.
27.    Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Chiou CH, Hsu YW, Ho, Su-Chen, Chu CH. “Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity” Clin. Endocrinol. Vol. 61, 2004, pp. 88-93.
28.    Ho, Su-Chen, Tsai, Po-Jung, ”Comparison of the effects of "hot" and "cold" Chinese medicinal plants on the production of inflammatory mediators by RAW 264.7 cells” Journal of Food and Drug Analysis, Vol. 12, No. 2, 2004, pp. 120-127.

Research Interest: Dietetics Applied to Bariatric Ssurgery; Clinical Impact of Bariatric Surgery on Patient’s Body Composition (Fat Mass and Fat-Free Mass) and Resting Metabolic Rate; Pre- and Post-Operative Treatment of Micronutrient Deficiencies in Patients that Underwent Bariatric Surgery.

China Diabetes Impact Study is funded by IDF and technically supported by Division of Diabetes Translation of CDC. It is a follow-up study of China National Diabetes and Metabolic Disorder Study. A total of 12 study sites participated in the China Diabetes Impact Study. I am the national program coordinator and the investigator of Beijing study site. All study participants with DM, NDM and IGR were interviewed and collected information about their health care service use, medical expenditure, etc.