Abstract

    Open Access Editorial Article ID: IJCEM-11-164

    Non-alcoholic Fatty Liver Disease (NAFLD) and Mesenchymal Stem Cell-derived Extracellular Vesicles: Current Status and Perspective

    Carmine Finelli* and Simone Dal Sasso

    Intrahepatocyte triglyceride buildup and concurrent immune system activation, followed by histological alterations, tissue destruction, and clinical manifestations, are signs of Non-alcoholic Fatty Liver Disease (NAFLD). One promising method of treating diabetes is cell-based therapy. In regenerative medicine, Mesenchymal Stem Cells (MSCs), which can be isolated from various tissue sources, such as  bone marrow, adipose tissue, umbilical cord, and mobilized peripheral blood, have gained increasing significance . Mesenchymal Stem Cell (MSC)-derived Extracellular Vesicles (EVs) (MSC-EVs) are novel cell-free carriers with minimal immunogenicity that might inhibit harmful immune responses in tissues that are inflamed. EVs may reduce inflammation in liver conditions. Advancement in the clinical translation of EVs necessitates enhanced interdisciplinary collaboration  between EV researchers, nanomedicine specialists, regulatory agencies, and clinical institutions is required. However, further in vitro and in vivo studies are required for better understanding cross talk between EVs and immune cells to clarify the potency and mechanisms of action  of this novel potential therapeutic tool.

    Keywords:

    Published on: Apr 5, 2025 Pages: 4-6

    Full Text PDF Full Text HTML DOI: 10.17352/ijcem.000064
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat

    Indexing/Archiving

    Pinterest on IJCEM