Evaluation of effi cacy & safety of oral fi xed dose combination of probiotics in bacterial vaginosis

Arif Ahmed Faruqui*

Aim: To evaluate the effi cacy and safety of vaginal specifi c lactobacilli strain in management of bacterial vaginosis.

Method: A non-randomized, open labeled, non-comparative, multi-centric, study was conducted in total of 58 female patients suffering from bacterial vaginosis. Each patient was administered a combination of four strains of Lactobacilli. Vaginal pH, discharge, odor, itching and painful urination were performed at baseline, week 2 and week 4 as assessment parameters.

Result: At the end of study data was extractable in only 56 females (mean age was 34.57 ± 11 years). Associated BV symptoms like vaginal discharge, odor and painful urination reduced signifi cantly at week 4 as compared to baseline. The most frequently encountered symptom was vaginal discharge, vaginal pH, odor and itching. With a shift in pH<4.5, at the end of week 4 all females showed improvement in the vaginal microbiota. Tolerability of fi xed dose combination was found to be good and none of the subjects discontinued the treatment.

Keywords:

Published on: Aug 2, 2019 Pages: 34-37

Full Text PDF Full Text HTML DOI: 10.17352/jgro.000068
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