Dietary Modulation of the NLRP3 Inflammasome in Inflammatory Skin Disease: A Targeted Review

Andres D Parga*, Hannah Coven, Naif Hebo, Lejla Hodzic, Olivia Lim, Nickoulet Babaei and Selene M Kizy

The NOD-like receptor protein 3 (NLRP3) inflammasome plays a central role in the pathogenesis of numerous inflammatory skin diseases, including psoriasis, atopic dermatitis, acne, and hidradenitis suppurativa. Emerging evidence suggests that dietary factors can significantly modulate NLRP3 activation through pathways involving oxidative stress, mitochondrial dysfunction, toll-like receptors, and cytokine regulation. This review synthesizes findings from in vitro, in vivo, and clinical research studies, evaluating the influence of specific nutrients and dietary patterns on NLRP3 activity in skin-related contexts. Compounds such as omega-3 fatty acids, vitamin D, polyphenols, and flavonoids consistently demonstrated inhibitory effects on NLRP3 inflammasome activation, while Western dietary patterns, saturated fats, and hyperglycemic states were associated with its upregulation. Mechanistic insights across studies revealed modulation of IL-1β, IL-18, ROS, ASC speck formation, and autophagy as key regulatory nodes. Translational findings highlight the potential for dietary interventions to complement pharmacologic therapies and mitigate chronic skin inflammation through targeted inflammasome suppression. By elucidating diet-inflammasome-skin interactions, this review supports the integration of nutritional strategies into the management of inflammatory dermatoses and offers a foundation for future interventional research.

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Published on: Jul 16, 2025 Pages: 13-21

Full Text PDF Full Text HTML DOI: 10.17352/2455-8605.000055
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