https://www.clinsurggroup.us/journals/international-journal-of-dermatology-and-clinical-research A Peertechz Open Access Journal en-us 27 Aug, 2025 https://www.clinsurggroup.us/articles/IJDCR-11-156.php Background: Granulomatous Mycosis Fungoides (MF) is a rare subtype of cutaneous T-cell lymphoma characterized by granulomatous inflammation. While MF is relatively well-known in dermatological practice, its association with prosthetic implants, particularly knee prostheses, is exceedingly rare. This case presents a novel instance of granulomatous MF potentially triggered by the chronic inflammation associated with a metallic knee prosthesis. Case description: We report the case of an 87-year-old female patient with ischemic heart disease and a total knee prosthesis, who presented with erythematous arcuate rash and nodules confined to the area around her right knee. Histopathological findings revealed non-necrotizing granulomas with epidermotropism, and immunohistochemistry confirmed the presence of CD4+/CD8+ T-cell infiltration, consistent with a diagnosis of granulomatous MF. The association between her prosthetic knee and the development of this condition is discussed. Conclusion: This case represents one of the first documented instances of granulomatous MF potentially linked to knee prosthesis. It highlights the need for vigilance in monitoring patients with prosthetic implants for rare, chronic inflammatory responses that may lead to lymphoproliferative disorders. 16 Jul, 2025 https://www.clinsurggroup.us/articles/IJDCR-11-155.php The NOD-like receptor protein 3 (NLRP3) inflammasome plays a central role in the pathogenesis of numerous inflammatory skin diseases, including psoriasis, atopic dermatitis, acne, and hidradenitis suppurativa. Emerging evidence suggests that dietary factors can significantly modulate NLRP3 activation through pathways involving oxidative stress, mitochondrial dysfunction, toll-like receptors, and cytokine regulation. This review synthesizes findings from in vitro, in vivo, and clinical research studies, evaluating the influence of specific nutrients and dietary patterns on NLRP3 activity in skin-related contexts. Compounds such as omega-3 fatty acids, vitamin D, polyphenols, and flavonoids consistently demonstrated inhibitory effects on NLRP3 inflammasome activation, while Western dietary patterns, saturated fats, and hyperglycemic states were associated with its upregulation. Mechanistic insights across studies revealed modulation of IL-1β, IL-18, ROS, ASC speck formation, and autophagy as key regulatory nodes. Translational findings highlight the potential for dietary interventions to complement pharmacologic therapies and mitigate chronic skin inflammation through targeted inflammasome suppression. By elucidating diet-inflammasome-skin interactions, this review supports the integration of nutritional strategies into the management of inflammatory dermatoses and offers a foundation for future interventional research. 28 May, 2025 https://www.clinsurggroup.us/articles/IJDCR-11-154.php The results of epidemiological studies conducted in divergent countries demonstrate the high prevalence of Atopic Dermatitis (AD) and the dynamics of the increase in the incidence of this pathology over the past decades. According to current research, AD is a multi-factorial disease, the pathogenesis of which is associated with both mutations in genes encoding epidermal structural proteins and epigenetic changes in gene expression. Generally accepted methods of treating skin damage in AD allow achieving remission, but not achieving a complete cure. It is shown that the composition of exosomes having a plasma origin can be supplemented with biologically active molecules introduced into the pericellular medium. The results obtained under the conditions of damage modeling in in vitro suggest that the use of exosomes for correcting the epigenetic landscape of cells under in vitro damage conditions is promising. 13 May, 2025 https://www.clinsurggroup.us/articles/IJDCR-11-153.php Narrowband UVB is used by dermatologists to treat atopic dermatitis and psoriasis. Although multimodal in its mechanism of action, the photo-oxidation of L-tryptophan to 6-formylindolo [3,2-b] carbazole, a potent Aryl Hydrocarbon Receptor (AHR) agonist, is proposed to play a role. This study aimed to assess AHR induction in patients treated with Narrowband UVB (NBUVB). 10 patients undergoing NBUVB therapy for psoriasis and atopic dermatitis had biopsies taken from a treatment site, with photo-protected buttock skin used as the control. Fitzpatrick skin types were one to three. Ages ranged from 29 to 82, with a median age of 63. The sex ratio was 4:6 (M: F). NBUVB was introduced at a commencing dose of 100 mJ with 20% increments three times weekly. Following 36 sessions of therapy, 4 mm punch biopsies were taken. Cytochrome P450 1A2 (CYP1A2) immunohistochemistry was used as a marker for AHR activity. Analysis was via Aperio Imagescope using Positive Pixel Count v9. Values for total intensity/mm2 were used to assess enzyme activity. A value of 45395360 was obtained at the control site and 5060956 at the treatment site with a p value of 0.12, which, although a positive result, fails to reach statistical significance. The interpretation of these results is complicated by the fact that FICZ is active at femtomolar concentrations, and a demonstration of a statistically significant effect on AHR induction via immunohistochemistry may be difficult. 20 Mar, 2025 https://www.clinsurggroup.us/articles/IJDCR-11-152.php A randomized controlled blinded pilot trial to evaluate the expression of key biomarkers of a topical cream comprising a unique blend of Herbal Extracts (HE) providing anti-inflammatory and stratum corneum repair compared to Tretinoin (Tr) 0.02% cream. Eight peri and post-menopausal women of skin types I-III with moderate to severe photodamage on forearms were evaluated. Two biomarkers for presence of photoaging revealed no statistically significant difference (p < 0.05) between HE and the prescription Tr product . These biomarkers include Fibrillin Ab and procollagen 2. Peroxisome Proliferator Activated Receptor (PPAR) gamma which is a biomarker for epidermal and stratum corneum repair was also tested. Compared to Tr, HE reached a trend toward statistical significance (p = 0.075) superiority in modulating PPAR gamma. 18 Dec, 2024 https://www.clinsurggroup.us/articles/IJDCR-10-151.php Acne vulgaris is a widespread chronic inflammatory skin illness that is primarily caused by inflammation, irregular skin cell turnover inside hair follicles, increased sebum production, and Propionibacterium acnes bacterial overgrowth. This comprehensive overview examines the intricate causes of acne vulgaris. The paper highlights the significant role of genetic predisposition, hormonal fluctuations, and environmental factors in acne development. Various in vivo and in vitro models, including mouse ear edema, rat models, and advanced techniques like 3D bioprinting and organ-on-a-chip systems, are discussed for their utility in studying acne pathogenesis and testing therapeutic interventions. The review underscores the importance of integrating diverse models to enhance understanding of acne mechanisms and improve treatment strategies, while also acknowledging the limitations of current models in replicating the complexity of human skin. Future research should focus on refining these models to better capture the multifactorial nature of acne and facilitate the development of effective, targeted therapies. 28 Nov, 2024 https://www.clinsurggroup.us/articles/IJDCR-10-150.php Bazex syndrome is a rare form of paraneoplastic syndrome affecting the skin, rarely identified as an underlying cancer cause at presentation. The current case highlights, as well as a literature review of cases, a 76-year-old man with a smoking history and no skin medical history who had a delayed diagnosis of Non-Small Cell Lung Cancer (NSCLC). Initial pre-diagnosis skin plaque treatment failed, with progressing shortness of breath leading to a finding of lung cancer. Plaques were classical in this case and did respond to the chemotherapy as previously reported, but not previously noted with the combination used in this case. Although the skin plaques responded to treatment, the patient did eventually die of advancing lung cancer. 21 Dec, 2023 https://www.clinsurggroup.us/articles/IJDCR-9-149.php Background: The formation of scars is fairly inevitable after open rhinoplasty and alar base procedures. Oftentimes, patients exhibit insecurities or discomfort at the appearance of these scars. CO2 laser resurfacing has been proposed as an effective treatment to minimize the appearance of surgical scars. Objective: To demonstrate the effectiveness of fractionated CO2 laser in the minimization of the appearance of surgical scars. Methods: Retrospective analysis of a rhinoplasty surgeon’s database as well as blinded grading of 54 consecutive alar wedge scars using Vancouver Scar Scales. Results: No complications were seen with the use of fractionated CO2 lasers as a treatment on rhinoplasty scars. No difference was seen in scar appearance, including scar height, vascularity, pliability, and scar height after one treatment of CO2 laser. Conclusion: A single treatment of fractionated CO2 laser does not improve scars. Multiple sessions of fractionated CO2 laser could be a more effective treatment for the appearance of surgical scars. 24 Nov, 2023 https://www.clinsurggroup.us/articles/IJDCR-9-148.php Introduction: Crusted scabies are a rare manifestation of scabies characterized by uncontrolled proliferation of mites in the skin. Crusted scabies are a severe variant of highly contagious scabies. Various cutaneous, neurologic and immunologic diseases have been described to predispose to crusted scabies. Case presentation: The presented case is a 7-month-old male. He was hospitalized at the Clinic of Dermatovenerology, due to hyperkeratotic changes in the palms and food, papules throughout the body, and nail changes all of these accompanied by scratching. Initially, it was diagnosed as atopic dermatitis, hyperkeratosis palmoplantaris, and onychomycosis mani. The changes had started to appear five months ago. Also, the mother of the child presents the papules throughout the body, also associated with itching as classical scabies. Conclusion: Crusted scabies are a severe variant of highly contagious scabies. Is known the failure of the immune system to suppress the proliferation of the mite is an important cause of crusted scabies development. Crusted scabies usually do not present as an acute eruption as in classical scabies. The eruption is slow in onset and insidious in progression. In the present case, we learned that in the stimulation of the condition, there was a major role in the application of topically fluoride steroids. 22 Mar, 2023 https://www.clinsurggroup.us/articles/IJDCR-9-147.php Background: Recessively inherited X-linked Ichthyosis (XLI) is the second most generic form of Ichthyosis and is characterized by scaly, dry, thickened, and mild erupted skin. It is caused by a mutation in the STS gene ensuing lower production of Steroid sulfatase. A current study was performed to characterize XLI and its complications in patients of Bajaur Agency, Pakistan. We also wanted to record critical factors affecting the progression of XLI. Methods: An Ichthyosis examination questionnaire was prepared and detailed information about the symptoms and management was recorded from 51 affected male patients of 17 families. Personal data such as age and gender were also recorded. Results: Our results indicate that 53% of the patients were collodion while other symptoms appeared in the first month after birth. Almost every part of the patient has symptoms of the disease; scales were found on the extensor and flexor muscles (98%) of limbs followed by the ears (82.53%). All the patients had normal nails, palms and soles. Conclusion: The age of the patients seems to have a significant effect on the color of the scales changing from white to brown to blackish. The disease progresses with the age and worsens in cold, dry seasons. The pedigrees of all families show that disease passes from generation to generation according to the classical X-linked recessive inheritance. We recommend early diagnosis and treatment for effective management of the condition. Further work is required to elucidate the genetic, biochemical, and environmental factors involved in the disease. 15 Dec, 2022 https://www.clinsurggroup.us/articles/IJDCR-8-146.php Dioxygen (the O2 molecule) is an important component of all tissues including skin. Even small fluctuations of O2 amount (dioxygen concentration changes in the tissue microenvironment) can strongly affect the signaling functions of cells through the reactive oxygen species (ROSs) activity and hence - the whole cellular metabolism, the cell proliferation, and differentiation, etc [1,2]. 26 Jul, 2022 https://www.clinsurggroup.us/articles/IJDCR-8-145.php Skin is the largest organ of the human body and acts as a protective barrier as our first line of defense. The development of effective treatments for skin diseases represents one of the biggest challenges in drug discovery. The pathogenesis of many skin disorders is complex and multifactorial. 25 Jul, 2022 https://www.clinsurggroup.us/articles/IJDCR-8-144.php Among the many plants used in traditional medicine in many countries, Averrhoa carambola L. and lonicera japonica Thunb are regularly the subjects of publications describing the pharmacological effects of their extracts. 30 Mar, 2022 https://www.clinsurggroup.us/articles/IJDCR-8-143.php Leiomyoma is a rare benign tumor of smooth muscle. In the word leiomyomas, “Leio” means “smooth”, “myo” means ‘muscle’, and “oma” means ‘tumor’. It may arise from smooth muscles of the skin, uterus, bladder, urethra. Depending upon the origin of skin smooth muscles cutaneous leiomyomas are of three main types: 1. Piloleiomyoma or leiomyoma cutis or pilar leiomyoma derived from arrector pili muscle; 2. Genital leiomyoma or dartoic myoma is derived from smooth muscle of the scrotum, vulva, and areola of the nipple, and 3. Angioleiomyoma is derived from the media of blood vessels. We report one such rare case of multiple piloleiomyomas. 17 Mar, 2022 https://www.clinsurggroup.us/articles/IJDCR-8-142.php Introduction: Rheumatoid purpura is a systemic vasculitis of small vessels that is more common in children than in adults. The aim of our study was to revise the characteristics of rheumatoid purpura in adults. Methods: We conducted a retrospective descriptive and analytical study [June 2016 - June 2021], including all the patients hospitalized in the dermatology department of Ibn Rochd University Hospital for rheumatoid purpura. We first described the characteristics of adult patients aged over 18 years old, and then we compared them to those of the children (<18 years old) to determine the clinical features in adults. Results: A total of 18 adults (15 women/3 Men) and 9 children were collected. Adults had a mean age of 48 years [27-66 years]. Vascular purpura was constant, complicated by necrosis in 12 patients, bullae in 6 patients, and ulceration in 2 patients. Joint involvement was present in 16 patients. Ten patients presented digestive signs: epigastralgia (n= 4), abdominal pain (n= 8), and rectal bleeding (n= 2). Cutaneous biopsy showed leukocytoclastic vasculitis in all patients with IgA and C3 deposition in 13 patients. Renal involvement was present in 6 patients. After comparison with the children group, the particularities in adults were the absence of previous drug intake (p= 0.009), absence of pruritus (p= 0.009), presence of bullae (p= 0.05), presence of severe digestive involvement (p= 0.033), joint involvement (p= 0.003), and presence of anemia (p= 0.017). Conclusion: Rheumatoid purpura in adults is characterized by its severe clinical features. 24 Nov, 2021 https://www.clinsurggroup.us/articles/IJDCR-7-141.php Aspergillus is an all-pervasive mold with the potential to cause severe invasive infections in the immunocompromised. A rare cutaneous manifestation of Aspergillus infection, primary cutaneous aspergillosis (PCA), occurs in just 1-5% of invasive aspergillosis cases. Prompt treatment is indicated as PCA may progress to a disseminated state. We present a unique case of an immunocompetent individual diagnosed with PCA two weeks after trauma and subsequent surgery. 29 Jan, 2021 https://www.clinsurggroup.us/articles/IJDCR-7-140.php Background: Onychomycosis is a common infection of the nail bed that can negatively affect patient quality of life. The complete cure rate for systemic drugs is 23-37 % while the complete cure rate for topical drug therapy with efinaconazole is 27.7%. Laser Pharmacology™ presents a promising alternative using a dual-diode laser employing wavelengths of 635 nm and 405 nm to create a drug-like response in living tissue (Erchonia® Lunula Laser®; Erchonia Corporation. Melbourne, FL). The purpose of this clinical study is to assess the safety and efficacy of mycological and complete cure rates of the dual diode nonthermal laser. Methods: Enrolled subjects (N=20) had onychomycosis affecting the great toenail, confirmed by a positive mycological culture. Subjects were predominantly female (70%) with a mean (SD) age of 59.9 (9.0) years. Affected toenails were treated with 12-minute laser light sessions, each week for 4 weeks, then one session at 3, 5, 7, 9 and 11 months. Study assessments were completed at 3, 5, 7, 9, 11, 12 and 14 months. Results: Most subjects achieved a Clinical Cure (n=14, 70%) and Mycological Cure (n=19, 95%) of the affected great toenail. At 12 months, most subjects also achieved Clinical Efficacy (n=18, 90%), Mycological Cure (n=19, 95%) and unaffected New Nail Growth (n=20, 100%). Conclusion: This study confirms the safety and effectiveness of a non-thermal 635 nm/405 nm dual-diode laser device for providing mycological and complete cure rate in onychomycosis-affected toenails following four weekly and five bi-monthly treatment sessions. Trial registration: ClinicalTrials.gov Identifier NCT03066336, registered 02/28/2017, https://clinicaltrials.gov/ct2/show/NCT03066336 17 Oct, 2020 https://www.clinsurggroup.us/articles/IJDCR-6-139.php Primary cutaneous follicle center lymphoma (PCFCL) is a rare type of indolent, low-grade cutaneous B-cell lymphoma, most frequent in trunk, particularly the head and scalp. Differential diagnosis for exclude other pathologies is needed. Here, we describers a detailed analysis on the expression profile of immunological and vascular mediators in tumor microenvironment that contribute to the knowledge, prognostic and diagnostic aid in a rare case of paravertebral PCFCL mimicking clinical appearance and localization of an unusual sebaceous cyst in a 48-year-old woman without history of neoplasia. 18 Apr, 2020 https://www.clinsurggroup.us/articles/IJDCR-6-138.php The genital area is becoming more and more the object of new attentions and targeted treatments are developed to support its functionality and beauty. The female world is closer to the awareness that the health of this intimate area should be considered an integral part of the beauty routine of every woman according to the new «well-ageing» approach. 12 Mar, 2020 https://www.clinsurggroup.us/articles/IJDCR-6-137.php Introduction: Scalp microneedling is a procedure in which various microchannels are created in the skin which have help in penetration and absorption of various agents into the skin. Aims: To compare the efficacy of microneedling with minoxidil solution versus microneedling with hair multivitamin solution for the treatment of twenty patients of male androgenetic alopecia. Methods: We selected twenty patients of androgenetic alopecia for the study. The patients were divided into two groups of ten patients each. In group I patients, microneedling with dermaroller was done and then minoxidil solution was applied over the scalp. In group II patients, microneedling was done and hair cocktail solution containing biotin and panthenol was used. 27 Feb, 2020 https://www.clinsurggroup.us/articles/IJDCR-6-136.php Background: Although prior studies have examined the effect of radiation-induced skin toxicity on patients’ Quality of Life (QOL), little is known about the effect of radiotherapy on skin-related QOL with different radiotherapy schedules. Objective: To assess the impact of radiodermatitis on the quality of life in patients undergoing conventionally fractionated versus hypofractionated radiation therapy for breast cancer. 21 Feb, 2020 https://www.clinsurggroup.us/articles/IJDCR-6-135.php Toxic Epidermal Necrolysis (TEN) and Steven Johnson Syndrome (SJS) are usually of drug-related reasons and infectious etiology. This is often defined by detachment of cuticle and lysis. SJS-TEN OVERLAP is TEN and SJS like syndrome characterized by involvement of more than 10% body surface area. But it is limited within 30%. Different types of purpuric macules or rounded patches with mucosal lesions are the characteristic features of this type 3 hypersensitivity reaction. SJS/TEN overlap uninterruptedly presented with fever for 2-3 days. 10 Dec, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-134.php Background: To our knowledge there has been no previous report in the literature of persistent diffuse itching caused by an organic foreign body. Case presentation: The patient, 81-year-old woman, had suffered over the previous six months from diffuse itching of the scalp, the chest, and the abdomen. 13 Nov, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-133.php Psoriasis is a chronic infl ammatory skin disease that affects 2% to 4% of the population. Infl ammatory arthritis develops in approximately 30% of patients with psoriasis and can have a major effect on activities of daily living and quality of life. 20 Jul, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-132.php Background: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, having therefore, a worse prognosis. Increasing knowledge of risk factors that contribute to a better prognostic evaluation is considered of interest. 02 Feb, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-131.php Nε-(carboxymethyl) lysine (CML), an advanced glycation end product (AGE), is an aging factor produced by glycation of protein. Higher levels of AGE in skin tissue are related to skin elasticity, but how CML that has accumulated in the skin affects hair follicle formation is unclear. This study constructed a simple model that mimics accumulated glycation from feeding by intradermally injecting Nε-(carboxymethyl) lysine (CML), and examined the effects on the morphogenesis of hair follicles (HF). The results showed weakening of the hair shaft and HF formation by CML. The in vitro inhibitory effect of CML on wound healing of dermal papilla cells (DPC) suggested that the mechanism influences the proliferation and migration of DPC, which are essential for HF morphogenesis. 25 Jan, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-130.php Immunoglobulin A (IgA) Vasculitis, more commonly known as Henoch-Schönlein Purpura (HSP), is a disorder which causes inflammation and bleeding in the small blood vessels of the skin, joints, intestines, and kidneys. We report 2 cases of IgA vasculitis found in a rural emergency department: 1) HSP in an 8-year-old male who was initially misdiagnosed with insect bites 2) HSP in an adult male patient. We present both cases and a literature review, indicating that low incidence may be secondary to under diagnosis, arguing for a need of further education on the subject. 12 Jan, 2019 https://www.clinsurggroup.us/articles/IJDCR-5-129.php A nineteen year old girl presented with rashes of chicken pox and inability to close both eyes properly for two days. She had difficulty in eating and smiling. 20 Dec, 2018 https://www.clinsurggroup.us/articles/IJDCR-4-128.php Incontinentia pigmenti is a rare X-linked neuroectodermal dysplasia estimated to occur in approximately 1:50,000 births. It’s first clinical manifestations are unique cutaneous lesions comprehending four different stages that emerge throughout the first year of life and persist until adolescence. One third of these patients develop central nervous system and ocular manifestations, causing great disability. The authors report the case of a patient with vesicular cutaneous lesions within 5 days after birth, with a fast and uncommon evolution. Although rare, the early identification of this disorder can prompt thorough investigation of associated comorbidities and adequate familiar and medical assistance. 06 Nov, 2018 https://www.clinsurggroup.us/articles/IJDCR-4-127.php The male Z-plasty necklift (MZPN) is a well described procedure [1-4], specifi cally used for men with severe aging neck changes who cannot be achieve a satisfactory aesthetic outcome with other necklift procedures that are performed through a submental incision. 02 Nov, 2018 https://www.clinsurggroup.us/articles/IJDCR-4-126.php Background: Candida is an ubiquitious organism causing superfi cial fungal infections that are commonly encountered in clinical practice. The knowledge of the change in the epidemiology, clinical spectrum and antifungal susceptibility may aid for the appropriate treatment decisions. 09 Apr, 2018 https://www.clinsurggroup.us/articles/IJDCR-4-125.pdf The frequency of association between systemic sclerosis and primary biliary cholangitis is 5-10% and usually the first manifests as a CREST syndrome [4, 5]. In limited systemic sclerosis, 8% of antimitochondrial antibodies and 9-29% anti-Ro antibodies have been reported [6]. 12 Dec, 2017 https://www.clinsurggroup.us/articles/IJDCR-3-124.php Candidasis is the most common superficial fungal infection in immunocompromised patients. With the advent of wide spectrum of immunosuppressive drug and increase in HIV patients, there is a change in the epidemiology and clinical presentation of mucocutaneous candidiasis. 31 Oct, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-123.php Chronic urticaria is one of the most frequent skin diseases and still its etiology is recognized only in a minority of cases. Some recent studies point out to infections due to Helicobacter Pylori as being of major importance in the pathogenesis of chronic urticaria. This study aimed to find out the association of chronic urticaria with H. pylori 21 Sep, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-122.php Introduction: The increase of both the frequency and severity of the bacterial dermohypodermitis (BDH) in Senegal suggests the existence of other risk factors outside of those classically known to be involved. Our study aimed to clarify the epidemiological, clinical and risk factors of BDH in Senegal. 09 Sep, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-121.php Tinea Corporis is a superfi cial fungal infection affecting 20-25% of the world’s population. Management involves using topical and oral antifungal drugs. Terbinafi ne has been used commonly for the treatment of tinea corporis to prevent the emergence of resistance combination of drugs is used. Hence, this study was designed to compare the safety and effi cacy of Sertaconazole and Amphotericin B when either is used with oral Terbinafi ne. 06 Jul, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-120.php Curcumin, the active ingredient in the spice turmeric, has been used in many Eastern countries for its known anti-infl ammatory activity. Recently, 15 Jun, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-119.php Jessner’s lymphocytic infi ltrate of the skin is a rare, benign cutaneous disorder. Diffi culty arises in differentiating it from cutaneous lymphoma on histology, thus requiring immunophenotying, however the literature lacks reports demonstrating malignant transformation or dual pathology. 25 Apr, 2017 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-3-118.php Background: Obesity is a major public health concern worldwide. Limited number of studies on the relationship between obesity and skin disease are available 24 Sep, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-117.php Introduction Nonpustular annular psoriasis is a rare form of psoriasis with clinically annular ring-shaped configuration [1]. In contrast to recurrent circinate erythematous psoriasis (Psoriasis a type d’erytheme circine recidivant de Bloch) [2], which is the mildest form of pustular psoriasis, no evidence of histopathological Kogoi’s spongiform pustule formation is detected. 23 Sep, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-116.php Letter Localized myxedema may be observed in hypo/hyperthyroidism [1]. However, the affected sites are usually pretibial area and the lesion on the eye lid is rare. We report a case of myxedema on the bilateral upper eyelids, which was a diagnostic clue of hypothyroidism associated with Hashimoto disease. 27 Aug, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-115.php Introduction Cutaneous angiosarcoma is an uncommon malignant vascular tumor with a highly variable presentation. It has a predilection for elderly Caucasian men, with 50% of tumors occurring primarily on the head and neck [1]. Cutaneous angiosarcomas may also occur in sites with chronic lymphedema, areas of prior radiation therapy, and in association with vascular and peripheral nerve sheath tumors [1]. Review of the literature reveals three reports of angiosarcoma arising on the head and neck of those with concomitant systemic sclerosis. There is also one report of angiosarcoma and morphea arising in a site of irradiation. 02 May, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-114.php Letter Sir, India alone, contributes about 58.8% and 81.2% of the newly detected cases of leprosy, globally and in the South East Asian region, respectively [1]. Cases were detected mainly by passive surveillance. Detection of leprosy cases will lead to a diminution of the source of infection in the community, mainly because undetected and untreated cases will transmit the disease agent to other people in the community. Pockets of high endemicity are still prevalent in a few states in India indicating ongoing disease transmission of leprosy. LCDC (Leprosy Cases Detection Campaign) is a first of its kind initiative taken by Govt of India, Ministry of Health and Family Welfare and was implemented in high endemic districts of the country, online with a pulse polio campaign in the months of March and April 2016 [2] 20 Feb, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-113.php Introduction Part 1 / skin tags Synonyms: Soft warts, achrochordon[1], cutaneous tag, papilloma colli, fibroma pendulum, cutaneous papilloma, fibroma molluscum, templeton skin tags [2], fibroepithelial polyps, pedunculated soft fibromas, filiform soft fibromas [3]. 08 Jan, 2016 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-2-112.php Dear Editor The Raynaud´s phenomenon (RP) is well known as the first sign of systemic scleroderma (SS) and related disorders. Its early diagnosis leads to a better understanding of the disease and favorable prognosis. 28 Dec, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-111.php Introduction Part I: Molluscum Contagiosum (MC) Definition: Molluscum Contagiosum (MC) is a benign viral infection that generally affects young children. It is characterized by smooth, dome-shaped discrete papules that occasionally develop surrounding area of scale and erythema (molluscum dermatitis) [1]. 17 Oct, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-110.php Introduction Vitiligo and melasma are acquired pigmentary disorder of the skin and also the leading cause for dermatologist consultation in South Asian countries like Nepal. Clinically vitiligo is characterised by well circumscribed, depigmented macules and patches secondary to selective destruction of melanocytes in the skin and mucous membrane, whereas melasma is characterized by symmetrical hyperpigmented macules on the face. 25 Sep, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-109.php Introduction Actinomycetoma is a chronic suppurative and or granulomatous infectious process caused by aerobic filamentous bacteria. Actinomycetomas are caused by members of genus Nocardia, Streptomyces, Nocardiopsis, and Actinomadura. 10 Sep, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-108.php Introduction Schamberg disease, also known as Schamberg purpura or progressive pigmentary purpura, is characterized by orange-brown or reddish-brown macules/patches with overlaying purpuric spots simulating “cayenne pepper” [1,2]. The condition was first described in 1901 by Jay Frank Schamberg who reported a 15-year-old boy with a 5-year history of “diffuse, reddish-brown, non-elevated, irregular oval patches with borders consisting of pin-head size, reddish-brown, scarcely elevated puncta or cayenne-pepper spots” [3]. The condition now bears his name. To our knowledge, Schamberg disease has not been reported in Chinese patients. The purpose of this communication is to alert the medical profession to the existence of this condition in Chinese patients so that the diagnosis would not be overlooked. 01 Sep, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-107.php Introduction Psoriasis, a chronic inflammatory immune-mediated disease involving the skin, nails, and the musculoskeletal structures, affects 1 to 3% of the world population [1]. Approximately 25% of patients develop the disease before 20 years of age [2]. It is reported that up to 90% of patients with psoriasis develop onychodystrophy at some point during their lives [3-5]. Nail involvement precedes the skin lesions in approximately 4% of patients [2]. We herewith report a 7-year-old boy who presented with psoriatic onychodystrophy at the age of 6 years followed by the development of plaque psoriasis 6 months later. 24 Aug, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-106.php Dear Editor, Annular elastolylic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by loss of elastic fibers accompanied with elastophagocytosis by multinucleated giant cells. The clinical appearance shows annular and serpiginous plaques with hypopigmentation or skin atrophy. 28 May, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-105.php Introduction Multiple autoimmune syndrome is defined by the coexistence of at least three different autoimmune diseases which can occur simultaneously or over several years of evolution. We report an exceptional association of vitiligo, autoimmune thrombocytopenia and autoimmune dermoepidermal bullous dermatosis. 27 Apr, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-104.php A 20 years-old-man, a native Indian of low socio-economic reckoning, had come to clinic with the complaints of severe nocturnal itching of the genitals for the past one month. A similar complaint was registered by other members of the household. The early diagnosis of the condition seemed to have been overlooked, because of conspicuous sparing of the usual sites namely the anterior axillary folds, elbows, wrists, webs of the fingers and around the umbilicus of the abdomen. Skin surface examination of the genitals, however, was remarkable, because it was studded by nodules of the size varying from 0.5 to 1cm. 31 Mar, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-103.php A 4 month year-old boy presented with a 5 day history of an erythematous exudative lesion on the lateral aspect of the face, neck and thorax. He had been observed by his physician and a topical fusidic acid ointment had been applied without success. His prior medical history was remarkable for an atopic dermatitis. On physical examination the patient had fever of 38.6ºC. 31 Mar, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-102.php Introduction The congenital melanocytic nevus is a type of melanocytic nevus found in infants at birth. This type of birthmark occurs in an estimated 1% of infants worldwide. It may be divided into the Small, medium-sized congenital nevocytic nevus and giant congenital melanocytic nevus also known as “Bathing trunk nevus,”. We report a case in a 42-year-old woman. 21 Mar, 2015 https://www.clinsurggroup.us/Dermatology-Clinical-Research/IJDCR-1-101.php Psoriasis is a skin disease that is evidenced primarily by plaques which can be seen throughout the body. Genetic predisposition that combines with an environmental trigger of the immune system is believed to be the root cause of psoriasis. This leads to signaling factors which coordinate the progression of inflammation and psoriatic plaques. Psoriatic patients commonly use topical agents, phototherapy, and systemic agents; however, biological therapies have become increasingly popular. This is primarily due to recent advances in the study of psoriasis which have shown that monoclonal antibodies and dimeric fusion proteins inhibit key signaling molecules within the inflammatory cascade such as TNFα, IL-12 and IL-23. This article reviews the advances made to understand the role of TNFα in the progression of psoriasis, discusses treatment options such as topical agents, phototherapy and systemic agents, and then compares a variety of monoclonal antibodies and dimeric fusion proteins as biological therapies.