A Comprehensive Survey on Models Used for Acnegenesi

Nituporna Bora* and Jutirani Devi

Acne vulgaris is a widespread chronic inflammatory skin illness that is primarily caused by inflammation, irregular skin cell turnover inside hair follicles, increased sebum production, and Propionibacterium acnes bacterial overgrowth. This comprehensive overview examines the intricate causes of acne vulgaris. The paper highlights the significant role of genetic predisposition, hormonal fluctuations, and environmental factors in acne development. Various in vivo and in vitro models, including mouse ear edema, rat models, and advanced techniques like 3D bioprinting and organ-on-a-chip systems, are discussed for their utility in studying acne pathogenesis and testing therapeutic interventions. The review underscores the importance of integrating diverse models to enhance understanding of acne mechanisms and improve treatment strategies, while also acknowledging the limitations of current models in replicating the complexity of human skin. Future research should focus on refining these models to better capture the multifactorial nature of acne and facilitate the development of effective, targeted therapies.

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Published on: Dec 18, 2024 Pages: 5-12

Full Text PDF Full Text HTML DOI: 10.17352/2455-8605.000051
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