Anal adenosquamous carcinoma on perineal fistula: A case report

Hajri Amal, Lamnaouar Abderrahmane, Falousse Kabira*, Erreguibi Driss, Boufettal Rachid, Saad Rifki El Jay and Farid Chehab

Introduction: Adenosquamous Carcinoma (ASC) of the anus presenting both glandular and squamous histopathologic features is a rare colorectal neoplasm.

Case presentation: A 63-year-old man presented with a one-year history of intermittent rectal pain and bleeding on a perineal fistula. Pathological analysis of the surgical specimen revealed adenosquamous carcinoma of the anus, The patient received neoadjuvant treatment with chemotherapy and radiotherapy over a period of five weeks. then he underwent abdominoperineal resection and a permanent colostomy. Histology revealed invasive adenosquamous carcinoma on the resection specimen and the patient was started on adjuvant therapy with FOLFIRINOX.

Discussion: Primary ASC of the colon and rectum are extremely rare clinical entities with poor prognosis. Most of the data come from individual case reports and a few small series, making it a challenge to understand the histogenesis of the disease. And the treatment modalities are not yet well codified, which has an impact on overall survival.

Conclusion: Early diagnosis and radical surgery with other available therapeutic modalities can improve clinical outcomes.

Keywords:

Published on: Mar 24, 2023 Pages: 4-7

Full Text PDF Full Text HTML DOI: 10.17352/2455-2283.000116
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